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RK-1355A and B, novel quinomycin derivatives isolated from a microbial metabolites fraction library based on NPPlot screening
TLDR
These are the first examples for natural products as a quinoline type quinomycin having a sulfoxide on the intramolecular cross-linkage and showed potent antiproliferative activities against various cancer cell lines and they were also found to exhibit moderate antibacterial activity.
Wakodecalines A and B, new decaline metabolites isolated from a fungus Pyrenochaetopsis sp. RK10-F058
TLDR
Two new decaline metabolites, wakodecalines A and B, were isolated from a fungus by screening for structurally unique metabolites using LC/MS analysis and showed moderate antimalarial activity against the Plasmodium falciparum 3D7 strain.
Pyrrolizilactone, a new pyrrolizidinone metabolite produced by a fungus
TLDR
The isolation of a novel compound from a fungi fraction library is reported, demonstrating the advantage of the fraction library in isolating novel metabolites from natural sources.
Verticilactam, a new macrolactam isolated from a microbial metabolite fraction library.
TLDR
A novel macrolactam, verticilactam (1), was isolated from a library of Streptomyces spiroverticillatus JC-8444 and had a unique 16-membered macrolACTam skeleton including a β-keto-amide moiety.
Opantimycin A, a new metabolite isolated from Streptomyces sp. RK88-1355
A new metabolite containing a γ-butyrolactone and 2-hydroxy-3formylaminobenzoic acid moieties, opantimycin A (1) was isolated from a microbial metabolite fraction library generated from Streptomyces
Unantimycin A, a new neoantimycin analog isolated from a microbial metabolite fraction library
TLDR
Unantimycin A, a new neoantimYcin analog isolated from a microbial metabolite fraction library reads shows promising results in terms of specificity and high-throughput analysis.
Spirotoamides A and B, novel 6,6-spiroacetal polyketides isolated from a microbial metabolite fraction library
Two new 6,6-spiroacetal polyketides, spirotoamides A (1) and B (2), were isolated from a microbial metabolite fraction library of Streptomyces griseochromogenes JC82-1223 by screening of structurally
RK-270A−C, new oxindole derivatives isolated from a microbial metabolites fraction library of Streptomyces sp. RK85-270
TLDR
Three new oxindole derivatives, RK-270A, B and C, were discovered and isolated from Streptomyces sp.
Heterologous Expression of the Biosynthetic Gene Cluster for Verticilactam and Identification of Analogues.
TLDR
Minor verticilactam derivatives were isolated from the transformed strain, and their structures elucidated by spectral analysis, showing moderate activity against the malaria parasite Plasmodium falciparum 3D7 strain with no significant cytotoxicity or antimicrobial effects.
Verticilactam, a New Macrolactam Isolated from a Microbial Metabolite Fraction Library.
The title compound, found in a metabolite fraction library of Streptomyces spiroverticillatus JC-8444, does not exhibit any antibacterial, antifungal or cytotoxic effects in vitro.
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