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  • Zhefeng Guo, Akiko Kumagai, Sherry X Wang, William G. Dunphy
  • Biology, Medicine
  • Genes & development
  • 2000 (First Publication: 1 November 2000)
  • The checkpoint kinase Xchk1 becomes phosphorylated in Xenopus egg extracts in response to DNA replication blocks or UV-damaged DNA. Xchk1 is also required for the cell cycle delay that is induced byExpand
  • Akiko Kumagai, Zijian Guo, K H Emami, Sophie Xuefei Wang, William G. Dunphy
  • Medicine, Biology
  • The Journal of cell biology
  • 1998 (First Publication: 21 September 1998)
  • We have analyzed the role of the protein kinase Chk1 in checkpoint control by using cell-free extracts from Xenopus eggs. Recombinant Xenopus Chk1 (Xchk1) phosphorylates the mitotic inducer Cdc25 inExpand