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Regulation of centriolar satellite integrity and its physiology
  • Akiko Hori, T. Toda
  • Biology, Medicine
  • Cellular and Molecular Life Sciences
  • 2 August 2016
Centriolar satellites comprise cytoplasmic granules that are located around the centrosome. Their molecular identification was first reported more than a quarter of a century ago. These particles areExpand
Reactive oxygen species regulate DNA copy number in isolated yeast mitochondria by triggering recombination-mediated replication
Mitochondrial DNA (mtDNA) encodes proteins that are essential for cellular ATP production. Reactive oxygen species (ROS) are respiratory byproducts that damage mtDNA and other cellular components. InExpand
Msd1/SSX2IP-dependent microtubule anchorage ensures spindle orientation and primary cilia formation
Anchoring microtubules to the centrosome is critical for cell geometry and polarity, yet the molecular mechanism remains unknown. Here we show that the conserved human Msd1/SSX2IP is required forExpand
DNA Recombination-Initiation Plays a Role in the Extremely Biased Inheritance of Yeast [rho−] Mitochondrial DNA That Contains the Replication Origin ori5
ABSTRACT Hypersuppressiveness, as observed in Saccharomyces cerevisiae, is an extremely biased inheritance of a small mitochondrial DNA (mtDNA) fragment that contains a replication origin (HS [rho−]Expand
Din7 and Mhr1 expression levels regulate double-strand-break–induced replication and recombination of mtDNA at ori5 in yeast
The Ntg1 and Mhr1 proteins initiate rolling-circle mitochondrial (mt) DNA replication to achieve homoplasmy, and they also induce homologous recombination to maintain mitochondrial genome integrity.Expand
A non‐canonical function of Plk4 in centriolar satellite integrity and ciliogenesis through PCM1 phosphorylation
Centrioles are the major constituents of the animal centrosome, in which Plk4 kinase serves as a master regulator of the duplication cycle. Many eukaryotes also contain numerous peripheral particlesExpand
Centriolar satellite– and hMsd1/SSX2IP-dependent microtubule anchoring is critical for centriole assembly
Human Msd1/SSX2IP is a component of centriolar satellites and essential for microtubule anchoring to the centrosome. Anchoring defects lead to abnormal accumulation of centriolar components atExpand
Mitochondrial fusion increases the mitochondrial DNA copy number in budding yeast
Mitochondrial fusion plays an important role in mitochondrial DNA (mtDNA) maintenance, although the underlying mechanisms are unclear. In budding yeast, certain levels of reactive oxygen speciesExpand
The conserved Wdr8-hMsd1/SSX2IP complex localises to the centrosome and ensures proper spindle length and orientation
The centrosome plays a pivotal role in a wide range of cellular processes and its dysfunction is causally linked to many human diseases including cancer and developmental and neurological disorders.Expand
GPR17 is an essential regulator for the temporal adaptation of sonic hedgehog signalling in neural tube development
ABSTRACT Dorsal-ventral pattern formation of the neural tube is regulated by temporal and spatial activities of extracellular signalling molecules. Sonic hedgehog (Shh) assigns ventral neuralExpand