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This paper discusses a structural optimization method that optimizes shape and topology based on the phase field method. The proposed method has the same functional capabilities as a structural optimization method based on the level set method incorporating perimeter control functions. The advantage of the method is the simplicity of computation, since(More)
Keywords: Topology optimization Finite element method Level set method Phase field method Tikhonov regularization method a b s t r a c t This paper proposes a new topology optimization method, which can adjust the geometrical complexity of optimal configurations, using the level set method and incorporating a fictitious interface energy derived from the(More)
Optimization of the lead 2a led to the identification of a novel diarylketoxime class of melanin-concentrating hormone 1 receptor (MCH-1R) antagonists. Our focus was directed toward improvement of hERG activity and metabolic stability. The representative derivative 4b showed potent and dose-dependent body weight reduction in diet-induced obese (DIO)(More)
Multi-axis force sensors are extensively utilized in engineering fields, for example in automotive development, where 6-axis force transducers are used to measure force components applied to wheels, and as sensors in robotic manipulators. These sensors are composed of sensing devices such as strain gages and transducer structures. The transducer structures(More)
A convergent and enantioselective route to the hNK-1 receptor antagonist (1) is described, which sets all six stereogenic centers with high diastereoselectivity and delivers 1 in only 11 steps and 23% overall yield. The process was enabled by the development of the enantioselective enzymatic reduction of 3-functionalized cyclopentenones and stereospecific(More)
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