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Histone chaperone FACT regulates homologous recombination by chromatin remodeling through interaction with RNF20
TLDR
A primary role of FACT is identified in RNF20 recruitment and the resulting chromatin remodeling for initiation of HRR, and the defective phenotypes of SUPT16H were effectively counteracted by enforced nucleosome relaxation.
Bisbenzamidine derivative, pentamidine represses DNA damage response through inhibition of histone H2A acetylation
TLDR
Results indicate that inhibition of Tip60 as well as hMRE11 nuclease by pentamidine underlies the radiosensitizing effects of this compound making it an excellent sensitizer for radiotherapy or chemotherapy.
HERC2 Interacts with Claspin and regulates DNA origin firing and replication fork progression.
TLDR
These findings establish HERC2 as a critical function in DNA repair, checkpoint activation, and DNA replication by suggesting that HerC2 regulates DNA replication progression and origin firing by facilitating MCM2 phosphorylation.
Srs2 and RecQ homologs cooperate in mei-3-mediated homologous recombination repair of Neurospora crassa
TLDR
This study identifies and characterizes the SRS2 homolog in Neurospora crassa, and finds that the N.crassa mus-25 (RAD54 homolog) mus-50 double mutant is viable, which is in contrast to the lethal phenotype of the equivalent rad54 srs2 mutant in S.cerevisiae.
Growth Defect and Mutator Phenotypes of RecQ-Deficient Neurospora crassa Mutants Separately Result From Homologous Recombination and Nonhomologous End Joining During Repair of DNA Double-Strand Breaks
TLDR
It is suggested that QDE3 and RECQ2 maintain chromosome stability by suppressing the formation of spontaneous DSBs, which are likely to be due to NHEJ acting on an elevated frequency of double-strand breaks (DSBs).
Identification and comparative analysis of the large subunit mitochondrial ribosomal proteins of Neurospora crassa.
TLDR
Individual mitochondrial ribosomal proteins of Neurospora crassa are purified and identified by mass spectrometry and compared with those of the budding yeast Saccharomyces cerevisiae to gain further insights into its structural and evolutionary characteristics.
Neurosprora crassa RAD5 homologue, mus-41, inactivation results in higher sensitivity to mutagens but has little effect on PCNA-ubiquitylation in response to UV-irradiation
TLDR
It was shown that mus-41 has a role independent from TLS gene upr-1 (REV3 homolog) and works in the error-free pathway, indicating that the function of mus- 41 as a RAD5 homolog is also conserved in N. crassa.
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