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BACKGROUND Galectin-9 (Gal-9) induces apoptosis in activated T helper 1 (TH1) cells as a ligand for T cell immunoglobulin mucin-3 (Tim-3). Gal-9 also inhibits the G1 phase cell cycle arrest and hypertrophy in db/db mice, the hallmark of early diabetic nephropathy, by reversing the high glucose-induced up-regulation of cyclin dependent kinase inhibitors such(More)
It is unknown whether adipokines derived from adipose tissues modulate endoplasmic reticulum (ER) stress induced in obesity. Here, we show that visceral adipose tissue-derived serine protease inhibitor (vaspin) binds to cell-surface 78-kDa glucose-regulated protein (GRP78), which is recruited from ER to plasma membrane under ER stress. Vaspin transgenic(More)
We discuss how to locate and manipulate the multi-viewpoint data set (MVDS) in virtual environment. Since MVDS has no geometric information in it, additional information, which links a virtual object represented by MVDS and geometry-based virtual space, should be attached to it. Without having that kind of information, no manipulation in virtual space is(More)
We analyzed the urine samples of patients with type 2 diabetes at various stages of diabetic nephropathy by lectin microarray to identify a biomarker to predict the progression of diabetic nephropathy. Japanese patients with type 2 diabetes at various stages of nephropathy were enrolled and we performed lectin microarray analyses (n = 17) and measured(More)
representation of complex objects without geometric models. Now the key to IBR future prosperity is how to accomplish functionalities of conventional geometry-based approaches. We have already reported how to interact with image-based objects in the virtual environment 3. The next goal is how to make objects without polygon models react to transition of(More)
PURPOSE Urinary angiotensinogen has been reported as a marker for the activation of intrarenal renin-angiotensin system (RAS) in various kidney diseases. To investigate the importance of urinary angiotensinogen in diabetic nephropathy, we compared the urinary levels of angiotensinogen, albumin, and α1-microglobulin. MATERIALS AND METHODS Japanese patients(More)