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- Keisuke Yamamoto, Takashi Sato, +5 authors Kazutoshi Mori
- Developmental cell
- 2007
Metazoans express three unfolded protein response transducers (IRE1, PERK, and ATF6) ubiquitously to cope with endoplasmic reticulum (ER) stress. ATF6 is an ER membrane-bound transcription factor… (More)
- Shigenori Nonaka, Yosuke Tanaka, +5 authors Nobutaka Hirokawa
- Cell
- 1998
Microtubule-dependent motor, murine KIF3B, was disrupted by gene targeting. The null mutants did not survive beyond midgestation, exhibiting growth retardation, pericardial sac ballooning, and neural… (More)
- Yosuke Tanaka, Yoshimitsu Kanai, +4 authors Nobutaka Hirokawa
- Cell
- 1998
Mouse kif5B gene was disrupted by homologous recombination. kif5B-/- mice were embryonic lethal with a severe growth retardation at 9.5-11.5 days postcoitum. To analyze the significance of this… (More)
- Nobutaka Hirokawa, Kenji Sobue, Kayoko Kanda, Akihiro Harada, Hiroshi Yorifuji
- The Journal of cell biology
- 1989
We have examined the cytoskeletal architecture and its relationship with synaptic vesicles in synapses by quick-freeze deep-etch electron microscopy (QF.DE). The main cytoskeletal elements in the… (More)
- Akihiro Harada, Keiko Oguchi, +7 authors Nobutaka Hirokawa
- Nature
- 1994
THE tau gene encodes a protein (Tau) that is a major neuronal microtubule-associated protein localized mostly in axons1–4. It has microtubule-binding and tubulin-polymerizing activity in vitro 3,4… (More)
- Akihiro Harada, Yoshio Takei, Yoshimitsu Kanai, Yosuke Tanaka, Shigenori Nonaka, Nobutaka Hirokawa
- The Journal of cell biology
- 1998
Cytoplasmic dynein, a minus end-directed, microtubule-based motor protein, is thought to drive the movement of membranous organelles and chromosomes. It is a massive complex that consists of multiple… (More)
- Takashi Sato, Sotaro Mushiake, +9 authors Akihiro Harada
- Nature
- 2007
A number of proteins are known to be involved in apical/basolateral transport of proteins in polarized epithelial cells. The small GTP-binding protein Rab8 was thought to regulate basolateral… (More)
- Yusuke Adachi, Keisuke Yamamoto, Tetsuya Okada, Hiderou Yoshida, Akihiro Harada, Kazutoshi Mori
- Cell structure and function
- 2008
Eukaryotic cells cope with endoplasmic reticulum (ER) stress by activating the unfolded protein response (UPR), a coordinated system of transcriptional and translational controls, which ensures the… (More)
Regulation of endocytic recycling by C. elegans Rab35 and its regulator RME-4, a coated-pit protein.
- Miyuki Sato, Ken Sato, Willisa Liou, Saumya Pant, Akihiro Harada, Barth D Grant
- The EMBO journal
- 2008
Using Caenorhabditis elegans genetic screens, we identified receptor-mediated endocytosis (RME)-4 and RME-5/RAB-35 as important regulators of yolk endocytosis in vivo. In rme-4 and rab-35 mutants,… (More)
- Yae Kanai, Yasunobu Okada, Yukichi Tanaka, Akihiro Harada, Sumio Terada, Nobutaka Hirokawa
- The Journal of neuroscience : the official…
- 2000
Kinesin superfamily proteins (KIFs) are the molecular motors conveying cargos along microtubules. KIF5s, the heavy chains of conventional kinesin (KHC), are originally identified members of KIFs, and… (More)