Akihiro Ametani

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PURPOSE The aim of this study was to evaluate human osteoblast activity on thin hydroxyapatite (HA)-coated three-dimensional scaffolds made of titanium fiber web. MATERIALS AND METHODS A thin HA film was coated on a titanium fiber web by the molecular precursor method. Human osteoblasts were disseminated onto the uncoated and HA-coated titanium fiber web,(More)
To accelerate the fabrication of in vivo tissue-engineered autologous vascular prosthetic tissues, the "Biotube," a novel wing-attached rod mold was designed for a tissue rolling technique based on a two-step in body tissue incubation (IBTI) process. The new mold consisted of a silicone rod (3-mm diameter, 23-mm length) partly connected to a poly(ethylene(More)
This study investigated the bone regeneration properties of titanium fibre mesh as a tissue engineering material. A thin hydroxyapatite (HA) coating on the titanium fibre web was created using the developed molecular precursor method without losing the complex interior structure. HA-coated titanium fibre mesh showed apatite crystal formation in vitro in a(More)
We compared osteoblast and osteoclast differentiation when using beta-tricalcium phosphate (βTCP) and titanium scaffolds by investigating human mesenchymal stem cells (hMSCs) and osteoclast progenitor cell activities. hMSCs were cultured for 7, 14, and 21days on titanium scaffolds with 60%, 73%, and 87% porosity and on βTCP scaffolds with 60% and 75%(More)
Coating biomaterials with a thin hydroxyapatite (HA) was proven effective in enhancing bone compatibility. Segmental bone defects are considered as the most difficult defect to repair in bone regeneration therapy. We developed submicron-thin HA-coated titanium fiber mesh scaffolds to reconstruct immediately loaded segmental mandibular defects and evaluated(More)
PURPOSE This study evaluated the bone-regeneration properties of titanium fiber web (TW) that had been coated with a thin hydroxyapatite (HA) layer using the molecular precursor method. MATERIALS AND METHODS TW disks with or without the thin HA coating were implanted into rat cranial bone defects. The rats were sacrificed after 3 or 6 weeks. New bone(More)
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