Akihiko Sakai

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BACKGROUND Various compounds have been detected in gingival crevicular fluid (GCF) as indicators of periodontal disease activity. Therefore, the analysis of GCF may be especially beneficial for diagnosing current periodontal status and addressing the effects of treatment. Moreover, the identification of new markers in GCF may also contribute to elucidating(More)
Hepatocyte growth factor (HGF) acts as a mitogen, motogen, morphogen, anti-apoptotic factor, and scatter factor for various kinds of epithelial cells. It is a protein secreted by mesenchymal cells such as fibroblasts, and promotes motility and matrix invasion of epithelial cells. To clarify whether HGF is involved in periodontal disease, this study was(More)
This study was a prospective, randomized, open, blinded endpoint study to assess the effects of angiotensin II type 1 receptor blocker, losartan, compared with calcium channel blocker, amlodipine, on left ventricular (LV) diastolic function and atherosclerosis of the carotid artery in Japanese patients with mild-to-moderate hypertension, LV hypertrophy,(More)
Hepatocyte growth factor (HGF) acts as a mitogen, motogen, morphogen, and anti-apoptotic factor for various kinds of epithelial cells. We previously showed that periodontal ligament and gingival fibroblasts secreted an HGF-like chemoattractant for a gingival epithelial cell line and found that the HGF content of gingival crevicular fluid was well correlated(More)
A 44-year-old man with right pheochromocytoma was scheduled for tumor resection. General anesthesia was maintained with nitrous oxide (66%), oxygen (33%), continuous infusion of propofol (4 mg.kg-1.hr-1), and continuous epidural block (1.5% mepivacaine 4 ml.hr-1). During operation, cardiac output and blood volume (BV) were measured by pulse dye-densitometry(More)
In order to evaluate the effects of propofol on neurologic outcomes of patients for carotid endarterectomy (CEA), intraoperative monitoring and postoperative complications were evaluated. Fifty two CEA cases were divided into two groups according to the method of anesthesia; group P (+) using propofol (n = 26), and group P (-) without propofol (n = 26).(More)
Recent studies have shown that the behavior of calcium in the epidermis is closely related to the conditions of the skin, especially the differentiation of the epidermal keratinocytes and the permeability barrier function, and therefore a correct understanding of the calcium dynamics is important in explaining epidermal homeostasis. Here we report on(More)
We studied 95 patients with a first anterior wall acute myocardial infarction who received successful reperfusion within 72 hours after the onset. The patients were divided into 4 groups based on the time required to achieve reperfusion; <3 hours (n = 23), 3 to 6 hours (n = 42), 6 to 24 hours (n = 17), and >24 to 72 hours (n = 13). The infarct size, as(More)