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Thrombin is a powerful agonist for platelets, the action of which is mediated by the thrombin receptor protease-activated receptor-1 (PAR-1). Recently, we discovered that E5555… (More)
Thrombin is a powerful agonist for a variety of cellular responses including platelet aggregation and vascular smooth muscle cell (SMC) proliferation. These actions are mediated by a thrombin… (More)
We present efficient syntheses of serofendic acids A and B (SA-A and SA-B), novel neuroprotective substances isolated from fetal calf serum. Biological and pharmacological evaluation showed that SA-A… (More)
By the use of a bromomethyl-cyclohexane derivative (7), which was synthesized from d-camphor (5), as the starting compound, two kinds of chiral segments, i.e. segment A-I (3) and segment A-II (4),… (More)
Analogues of serofendic acid were prepared and their protective effects against L-glutamate (Glu)-induced neurotoxicity were examined using primary cultures of rat cortical neurons. Some analogues… (More)
A chiarl 1,1,3-trimethylcyclohexane derivative (12), which is a potent key building block for synthesis of ent-taxane-type diterpenoids, has been prepared from d-camphor (2) through a conversion… (More)