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  • Misako Nakashima, Takashi Toyono, Akifumi Akamine, Alexandra Joyner
  • Medicine, Biology
  • Mechanisms of Development
  • 1999 (First Publication: 1 February 1999)
  • We have cloned and characterized a new member of the bone morphogenetic protein/transforming growth factor beta (BMP/TGFbeta) superfamily, growth differentiation factor 11 (Gdf11), from rat incisorContinue Reading
  • Naohisa Wada, Hidefumi Maeda, Yoshito Yoshimine, Akifumi Akamine
  • Biology, Medicine
  • Bone
  • 2004 (First Publication: 1 September 2004)
  • Our recent work showed that human periodontal ligament fibroblasts (HPLF) secrete bioactive osteoprotegerin (OPG), which inhibits osteoclastic differentiation and activity. However, it is unknown howContinue Reading
  • Koichiro Iohara, Misako Nakashima, Mamoru Ito, M Ishikawa, Akihiko Nakasima, Akifumi Akamine
  • Medicine
  • Journal of dental research
  • 2004 (First Publication: 1 August 2004)
  • Regenerative medicine is based on stem cells, signals, and scaffolds. Dental pulp tissue has the potential to regenerate dentin in response to noxious stimuli, such as caries. The progenitor/stemContinue Reading
  • Misako Nakashima, Koichiro Iohara, +4 authors Akifumi Akamine
  • Biology, Medicine
  • Human gene therapy
  • 2004 (First Publication: 1 November 2004)
  • Dental pulp progenitor/stem cells have the capacity to differentiate into odontoblasts and they provide a potential for dentin repair and regeneration by gene therapy. To develop a successful ex vivoContinue Reading
  • Nobuyoshi Akimitsu, Hiroshi Hamamoto, +5 authors Kazuhisa Sekimizu
  • Biology, Medicine
  • Antimicrobial agents and chemotherapy
  • 1999 (First Publication: 1 December 1999)
  • Methicillin-resistant Staphylococcus aureus (MRSA) has been found worldwide and is one of the major nosocomial agents. When MRSA strains were first discovered in hospitals, resistance of MRSA to lowContinue Reading
  • Mikio Shoji, Dinath B Ratnayake, +6 authors Koji Nakayama
  • Biology, Medicine
  • Microbiology
  • 2002 (First Publication: 1 April 2002)
  • A nonpigmented mutant of Porphyromonas gingivalis was constructed by using transposon mutagenesis. The mutant possessed the transposon DNA at the novel gene porR. Gene targeted mutagenesis revealedContinue Reading