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BACKGROUND AND PURPOSE Few studies have concerned the absolute apparent diffusion coefficient (ADC) values in the normal human brain and the effect of aging on diffusion. Therefore, our purpose was to determine whether the average ADC (ADC(av)) values in the various regions of the brain differ with age, sex, or hemisphere and to establish reference values(More)
Four different postprocessing methods to determine cerebral blood volume (CBV) and contrast agent mean transit time (MTT) by dynamic susceptibility contrast (DSC) MRI were compared. CBV was determined by two different methods that integrate tracer concentration-time curves numerically and by two other methods that take recirculation into account. For the(More)
We explored functional brain changes with positron emission tomography (PET) in mild cognitive impairment (MCI) patients and elderly normal controls by employing an episodic memory task that included two successive encoding trials of semantically related word-pairs and final retrieval. Both groups demonstrated significant learning across the two trials. The(More)
Radium-223-dichloride ((223)RaCl₂) is a new bone-seeking calcium analogue alpha-emitter, which has obtained marketing authorization for the treatment skeletal metastases of hormone-refractory prostate cancer. The current treatment regimen is based on six consecutive doses of (223)RaCl₂ at 4 week intervals and the administered activity dose, 50 kBq/kg per(More)
  • Jani Keyriläinen, Gustaf Hällströmin Katu, Heikki Joensuu, Thomlinson, Ossi Korhola, Docent Sauli Savolainen +15 others
  • 2004
former Beamline Responsible, ID17, for allowing me to use the outstanding working facilities of their institutions. Physicist of the Department of Oncology, for proposing to me the topic of this study and guiding me throughout this research work. Professor Suortti introduced me to the physics of X-ray diffraction; without the benefit of his world-renowned(More)
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