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  • Sakae Saito, Aki Furuno, Junko Sakurai, Hae-Ryong Park, Kazuo Shin-ya, Akihiro Tomida
  • Biology, Medicine
  • PloS one
  • 2012 (First Publication: 24 September 2012)
  • Inhibiting the unfolded protein response (UPR) can be a therapeutic approach, especially for targeting the tumor microenvironment. Here, we show that compound C (also known as dorsomorphin), aExpand
  • Yoshinori Tsukumo, Satomi Tsukahara, Aki Furuno, Shun-ichiro Iemura, Toru Natsume, Akihiro Tomida
  • Medicine, Biology
  • PloS one
  • 2014 (First Publication: 13 November 2014)
  • Under ER stress, PKR-like ER-resident kinase (PERK) phosphorylates translation initiation factor eIF2α, resulting in repression of global protein synthesis and concomitant upregulation of theExpand
  • Yoshinori Tsukumo, Satomi Tsukahara, Aki Furuno, Shun-ichiro Iemura, Tohru Natsume, Akihiro Tomida
  • Medicine, Biology
  • Biochemical and biophysical research…
  • 2015 (First Publication: 10 July 2015)
  • Transducin (beta)-like 2 (TBL2) is a poorly characterized protein comprising the N-terminal transmembrane region and the C-terminal WD40 domain. We previously showed that TBL2 is an endoplasmicExpand
  • Yoshinori Tsukumo, Satomi Tsukahara, Aki Furuno, Shun-ichiro Iemura, Tohru Natsume, Akihiro Tomida
  • Biology, Medicine
  • Journal of cellular biochemistry
  • 2016 (First Publication: 1 February 2016)
  • PKR-like ER-resident kinase (PERK) phosphorylates eukaryotic translation initiation factor 2 α (eIF2α) under endoplasmic reticulum (ER) stress; this results in repression of general translation andExpand