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The carcinogenic polycyclic aromatic hydrocarbons (PAHs) are active primarily at the site of entry to the body. Lung cancer following inhalation of PAH-containing aerosols such as tobacco smoke is(More)
Whole body autoradiographic studies performed with [3H]terbutaline after intravenous and oral administration in mice revealed that the tissue and organ radioactivity was similar to or lower than the(More)
BACKGROUND The isolated perfused rat lung (IPL) is a suitable model for studying lung-specific pharmacokinetics (PK) of inhaled drugs. So far, little has been known, however, whether the PK measured(More)