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A self-organized biomechanical network drives shape changes during tissue morphogenesis
Tissue morphogenesis is orchestrated by cell shape changes. Forces required to power these changes are generated by non-muscle myosin II (MyoII) motor proteins pulling filamentous actin (F-actin).Expand
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Actomyosin networks and tissue morphogenesis
Tissue morphogenesis is driven by coordinated cellular deformations. Recent studies have shown that these changes in cell shape are powered by intracellular contractile networks comprising actinExpand
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Modular activation of Rho1 by GPCR signalling imparts polarized myosin II activation during morphogenesis
Polarized cell shape changes during tissue morphogenesis arise by controlling the subcellular distribution of myosin II. For instance, during Drosophila melanogaster gastrulation, apical constrictionExpand
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Actomyosin pulsation and flows in an active elastomer with turnover and network remodeling
Tissue remodeling requires cell shape changes associated with pulsation and flow of the actomyosin cytoskeleton. Here we describe the hydrodynamics of actomyosin as a confined active elastomer withExpand
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Actomyosin pulsation and symmetry breaking flows in a confined active elastomer subject to affine and nonaffine deformations
Tissue remodelling in diverse developmental contexts require cell shape changes that have been associated with pulsation and flow of the actomyosin cytoskeleton. Here we describe the dynamics of theExpand
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Regulation of a bio-mechanical network driving shape changes during tissue morphogenesis
Forces required to power shape changes during tissue morphogenesis are generated by non-muscle MyosinII (MyoII) pulling filamentous actin. During my PhD, I investigated the role of MyoII regulationExpand
Extracellular hyaluronate pressure shaped by cellular tethers drives tissue morphogenesis
How tissues acquire complex shapes is a fundamental question in biology and regenerative medicine. Zebrafish semicircular canals form from invaginations in the otic epithelium (buds) that extend andExpand