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The lack of a quantitative framework that describes the dynamic relationships between infection and morbidity has constrained efforts aimed at the community-level control of lymphatic filariasis. In this paper, we describe the development and validation of EPIFIL, a dynamic model of filariasis infection intensity and chronic disease. Infection dynamics are(More)
Traditional fault tree (FT) analysis is widely used for reliability and safety assessment of complex and critical engineering systems. The behavior of components of complex systems and their interactions such as sequence-and functional-dependent failures, spares and dynamic redundancy management, and priority of failure events cannot be adequately captured(More)
Mathematical models of transmission dynamics of infectious diseases provide a useful tool for investigating the impact of community based control measures. Previously, we used a dynamic (constant force-of-infection) model for lymphatic filariasis to describe observed patterns of infection and disease in endemic communities. In this paper, we expand the(More)
There will be simplifying assumptions and idealizations in the availability models of complex processes and phenomena. These simplifications and idealizations generate uncertainties which can be classified as aleatory (arising due to randomness) and/or epistemic (due to lack of knowledge). The problem of acknowledging and treating uncertainty is vital for(More)
Probabilistic safety assessment (PSA) is the most effective and efficient tool for safety and risk management in nuclear power plants (NPP). PSA studies not only evaluate risk/safety of systems but also their results are very useful in safe, economical and effective design and operation of NPPs. The latter application is popularly known as ''Risk-Informed(More)
Risk informed in-service inspection aims at prioritising the components for inspection within the permissible risk level thereby avoiding unnecessary inspections. Various methods have been evolved for prioritisation, in which the importance measure approach has gained a wide popularity. This paper presents an importance measure that can be employed to(More)
Risk-Informed In-Service Inspection (RI-ISI) aims at prioritizing the components for inspection within the permissible risk level thereby avoiding unnecessary inspections. The two main factors that go into the prioritization of components are failure frequency and the consequence of the failure of these components. The study has been focused on piping(More)