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In rats with chronic gastric fistulas, prostaglandin F2 α stimulated the gastric acid secretion in graded doses of 50. 100, 200 and 400 μg/kg b. wt, while higher doses above 1 mg/kg b. wt tended to inhibit significantly. The gastric antisecretory effect of prostaglandin E1 could not be altered or modified by subsequent treatment of prostaglandin F2 α, while(More)
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