Ajit B. Jagdale

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The platelet-derived growth factor (PDGF) mediates its cellular functions via activation of its receptor tyrosine kinase followed by the recruitment and activation of several signaling molecules. These signaling molecules then initiate specific signaling cascades, finally resulting in distinct physiological effects. To delineate the PDGF signaling pathway(More)
Reactive oxygen species, including H2O2, play an important role in the tumor promotion process. Using an in vitro model of tumor promotion involving the rat liver epithelial oval cell line T51B, the tumor promoting activity of H2O2 in N-methyl-N'-nitro-N-nitrosoguanidine-initiated cells was studied. In this assay system, the promoting effect of H2O2 is(More)
Multielectrode recordings now reliably deliver simultaneous signals from a hundred or more neurons or networks. However, many analytic techniques are presently computationally limited to smaller numbers of signals, severely hampering our ability to relate these neural signals to brain functions including sensation, perception, decision, and action. To(More)
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