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Hippocampal proteoglycans brevican and versican are linked to spatial memory of Sprague–Dawley rats in the morris water maze
TLDR
Information about the PGs present in the rat hippocampus is provided, demonstrating that versican and brevican are linked to memory retrieval in the morris water maze and that PGs interact with α‐amino‐3‐hydroxy‐5‐methylisoxazole‐4‐propionate receptor GluR1, which is linked toMemory retrieval. Expand
Spatial and Working Memory Is Linked to Spine Density and Mushroom Spines
TLDR
Correlations between WME and latency in the RAM and spine density revealed a link between spine numbers and performance inThe RAM, and the study shows that spine numbers are significantly increased in the trained group, an observation that may suggest the use of this method representing a morphological parameter for memory formation studies in theRAM. Expand
A heterocyclic compound CE-103 inhibits dopamine reuptake and modulates dopamine transporter and dopamine D1-D3 containing receptor complexes
TLDR
CE-103 was shown to enhance spatial WM and DA reuptake inhibition with subsequent modulation of D1-3 receptors is proposed as a possible mechanism of action. Expand
Sex-Specific Regulation of Fear Memory by Targeted Epigenetic Editing of Cdk5
TLDR
It is found that male mice exhibit stronger long-term memory retrieval than do female mice, and this finding was associated with male-specific epigenetic activation of hippocampal Cdk5 expression, which may reflect differences in the effect of CDK5 on downstream target proteins that regulate memory. Expand
Frontal cortex and hippocampus neurotransmitter receptor complex level parallels spatial memory performance in the radial arm maze
TLDR
Two distinct RCs were paralleling performance in the RAM which is relevant for interpretation of previous and design of future work on RCs in memory studies. Expand
Changes of hippocampal beta-alanine and citrulline levels are paralleling early and late phase of retrieval in the Morris Water Maze
TLDR
An AA pattern, different between yoked and trained animals at early and late phase of memory retrieval is shown, indicating probable involvement of different AA pathways in animals trained and untrained in the MWM. Expand
The effect of modafinil on the rat dopamine transporter and dopamine receptors D1–D3 paralleling cognitive enhancement in the radial arm maze
TLDR
Modafinil was shown to enhance spatial WM in the rat in a well-documented paradigm at all the three doses and dopamine reuptake inhibition with subsequent modulation of D1–3-CC is proposed as a possible mechanism of action. Expand
A Novel Heterocyclic Compound CE-104 Enhances Spatial Working Memory in the Radial Arm Maze in Rats and Modulates the Dopaminergic System
TLDR
The effects upon cognition of a chemically synthesized novel MAT inhibiting compound 2-(benzhydrylsulfinylmethyl)-4-methylthiazole (named as CE-104) is examined to propose a possible mechanism for the observed learning and memory enhancement in the RAM. Expand
Distinct set of kinases induced after retrieval of spatial memory discriminate memory modulation processes in the mouse hippocampus
TLDR
A small signaling network associated with spatial memory retrieval is defined and differential regulation and correlation of expression levels with behavioral performance of polo‐like kinase 1 are described, suggesting a role of this kinase in balancing preservation and flexibility of learned behavior. Expand
Decreased hippocampal homoarginine and increased nitric oxide and nitric oxide synthase levels in rats parallel training in a radial arm maze
TLDR
Findings indicate that hArg is linked to NO formation in hippocampus but not in FL and is paralleling spatial memory in the RAM. Expand
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