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On the basis of studies carried out with a group of 47 patients with endogenous depressive illness, lower plasma activity of dopamine-beta-hydroxylase (DBH) was found as compared with a control group (31 healthy persons). Lower DBH activity particularly characterized bipolar patients. Lowest DBH activity was found in patients with a family history of(More)
The analysis of GABA levels in plasma of 28 normal persons and 25 patients with endogenous depression did not show any significant differences between both groups. Neither did we observe any differences in GABA levels in patients treated with antidepressant drugs before and after treatment, during a remission or a depression, in responders or nonresponders(More)
The final results of treatment with 4 antidepressants (amitriptyline, imipramine, chlorimipramine and mianserine) in 80 patients with endogenous depression were analyzed with respect to their pre-treatment levels of urinary MHPG. The analysis revealed that MHPG measurements were of no practical value in predicting individual response to antidepressants.