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- Wei Yu, Marta Gwinn, Melinda Clyne, Ajay Yesupriya, Muin J. Khoury
- Nature Genetics
- 2008
To the Editor: Recent successes in large-scale genetic association studies call for renewed attention to integrating research results, not only among studies, but across disciplines1. At the… (More)
- Man-huei Chang, Mary Lou Lindegren, +11 authors Muin J. Khoury
- American journal of epidemiology
- 2009
Population-based allele frequencies and genotype prevalence are important for measuring the contribution of genetic variation to human disease susceptibility, progression, and outcomes.… (More)
- Michael V Holmes, Caroline E. Dale, +152 authors Juan P. Casas
- BMJ
- 2014
OBJECTIVE
To use the rs1229984 variant in the alcohol dehydrogenase 1B gene (ADH1B) as an instrument to investigate the causal role of alcohol in cardiovascular disease.
DESIGN
Mendelian… (More)
- Ajay Yesupriya, Evangelos Evangelou, +8 authors Muin J. Khoury
- BMC medical research methodology
- 2008
BACKGROUND
Several thousand human genome epidemiology association studies are published every year investigating the relationship between common genetic variants and diverse phenotypes. Transparent… (More)
- Renée M. Ned, Ajay Yesupriya, +4 authors Nicole F. Dowling
- BMC Medical Genetics
- 2010
Albuminuria, a common marker of kidney damage, serves as an important predictive factor for the progression of kidney disease and for the development of cardiovascular disease. While the underlying… (More)
- Wei Yu, Melinda Clyne, +5 authors Marta Gwinn
- BMC Bioinformatics
- 2007
Synthesis of data from published human genetic association studies is a critical step in the translation of human genome discoveries into health applications. Although genetic association studies… (More)
- Man-huei Chang, Renée M. Ned, +5 authors Nicole F. Dowling
- Circulation. Cardiovascular genetics
- 2011
BACKGROUND
Genome-wide association studies (GWAS) have identified a number of single-nucleotide polymorphisms (SNPs) associated with serum lipid level in populations of European descent. The… (More)
- Wei Yu, Ajay Yesupriya, +4 authors Marta Gwinn
- European Journal of Human Genetics
- 2011
Genome-wide association studies (GWAS) have successfully identified numerous genetic loci that are associated with phenotypic traits and diseases. GWAS Integrator is a bioinformatics tool that… (More)
- Quanhe Yang, Leonard L. Bailey, +5 authors Jan M Friedman
- The American journal of clinical nutrition
- 2012
BACKGROUND
The association between blood homocysteine concentration and the risk of cardiovascular disease (CVD) remains controversial, but few studies have examined the association between MTHFR… (More)
- Christine Q Chang, Ajay Yesupriya, +6 authors Sheri D Schully
- European Journal of Human Genetics
- 2014
Candidate gene and genome-wide association studies (GWAS) represent two complementary approaches to uncovering genetic contributions to common diseases. We systematically reviewed the contributions… (More)