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Hypoxia-inducible factor 1 activation by aerobic glycolysis implicates the Warburg effect in carcinogenesis.

• Huasheng Lu, Robert A. Forbes, Ajay Verma
• The Journal of biological chemistry
• 2002

Cancer cells display high rates of aerobic glycolysis, a phenomenon known historically as the Warburg effect. Lactate and pyruvate, the end products of glycolysis, are highly produced by cancer cells… (More)

Hypoxia-inducible erythropoietin signaling in squamous dysplasia and squamous cell carcinoma of the uterine cervix and its potential role in cervical carcinogenesis and tumor progression.

• Géza Acs, Paul J Zhang, +6 authors Ajay Verma
• The American journal of pathology
• 2003

Tissue hypoxia is a characteristic property of cervical cancers that makes tumors resistant to chemo- and radiation therapy. Erythropoietin (Epo) is a hypoxia-inducible stimulator of erythropoiesis.… (More)

Reversible inactivation of HIF-1 prolyl hydroxylases allows cell metabolism to control basal HIF-1.

• Huasheng Lu, Clifton Lee Dalgard, Ahmed Mohyeldin, Thomas Mcfate, Alexandra S. Tait, Ajay Verma
• The Journal of biological chemistry
• 2005

Continuous hydroxylation of the HIF-1 transcription factor alpha subunit by oxygen and 2-oxoglutarate-dependent dioxygenases promotes decay of this protein and thus prevents the transcriptional… (More)

Pyruvate dehydrogenase complex activity controls metabolic and malignant phenotype in cancer cells.

• Thomas Mcfate, Ahmed Mohyeldin, +12 authors Ajay Verma
• The Journal of biological chemistry
• 2008

High lactate generation and low glucose oxidation, despite normal oxygen conditions, are commonly seen in cancer cells and tumors. Historically known as the Warburg effect, this altered metabolic… (More)

Withaferin A: a proteasomal inhibitor promotes healing after injury and exerts anabolic effect on osteoporotic bone

• Vikram Khedgikar, Priyanka Kushwaha, +10 authors Rachana Trivedi
• Cell Death and Disease
• 2013

Withania somnifera or Ashwagandha is a medicinal herb of Ayurveda. Though the extract and purified molecules, withanolides, from this plant have been shown to have different pharmacological… (More)

Transient receptor potential channel activation causes a novel form of [Ca 2+]I oscillations and is not involved in capacitative Ca 2+ entry in glial cells.

• Maurizio Grimaldi, Marina Maratos, Ajay Verma
• The Journal of neuroscience : the official…
• 2003

Astrocytes express transient receptor potential channels (TRPCs), which have been implicated in Ca 2+ influx triggered by intracellular Ca 2+ stores depletion, a phenomenon known as capacitative Ca… (More)

Immunohistochemical expression of erythropoietin and erythropoietin receptor in breast carcinoma.

• Géza Acs, Paul J Zhang, Timothy R. Rebbeck, Péter Acs, Ajay Verma
• Cancer
• 2002

BACKGROUND Erythropoietin (Epo), induced by hypoxia, controls the survival, proliferation, and differentiation of Epo receptor (EpoR)-bearing erythroid progenitors and plays a role in the protection… (More)

Erythropoietin signaling promotes invasiveness of human head and neck squamous cell carcinoma.

• Ahmed Mohyeldin, Huasheng Lu, +4 authors Ajay Verma
• Neoplasia
• 2005

Erythropoietin (Epo) is used for managing anemia in cancer patients. However, recent studies have raised concerns for this practice. We investigated the expression and function of Epo and the… (More)

Mitochondrial mutations contribute to HIF1alpha accumulation via increased reactive oxygen species and up-regulated pyruvate dehydrogenease kinase 2 in head and neck squamous cell carcinoma.

• W. Sun, Shaoyu Zhou, Steven S. Chang, Thomas Mcfate, Ajay Verma, Joseph A. Califano
• Clinical cancer research : an official journal of…
• 2009

PURPOSE Mitochondrial mutations have been identified in head and neck squamous cell carcinoma (HNSCC), but the pathways by which phenotypic effects of these mutations are exerted remain unclear.… (More)

Endogenous 2-oxoacids differentially regulate expression of oxygen sensors.

• Clifton Lee Dalgard, Huasheng Lu, Ahmed Mohyeldin, Ajay Verma
• The Biochemical journal
• 2004

Adaptations to change in oxygen availability are crucial for survival of multi-cellular organisms and are also implicated in several disease states. Such adaptations rely upon gene expression… (More)

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