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We present the first comprehensive analysis of a diploid human genome that combines single-molecule sequencing with single-molecule genome maps. Our hybrid assembly markedly improves upon the contiguity observed from traditional shotgun sequencing approaches, with scaffold N50 values approaching 30 Mb, and we identified complex structural variants (SVs)(More)
Restriction enzymes share little or no sequence homology with the exception of isoschizomers, or enzymes that recognize and cleave the same DNA sequence. We present here the structure of a BamHI isoschizomer, OkrAI, bound to the same DNA sequence (TATGGATCCATA) as that cocrystallized with BamHI. We show that OkrAI is a more minimal version of BamHI, lacking(More)
A major clinical problem in the use of cisplatin to treat cancers is tumor resistance. DNA polymerase η (Pol-η) is a crucial polymerase that allows cancer cells to cope with the cisplatin-DNA adducts that are formed during chemotherapy. We present here a structure of human Pol-η inserting deoxycytidine triphosphate (dCTP) opposite a cisplatin intrastrand(More)
This paper describes novel concepts of space bionanorobotic systems that are based on revolutionary bio-nano-mechanisms formed by protein and DNA based nano-components. Nano-robots are controllable machines at the nano (10-9) meter or molecular scale that are composed of nano-scale components. With the modern scientific capabilities, it has become possible(More)
This paper discusses about the relevance of detecting space radiations which are very harmful and pose numerous health issues for astronauts. There are many ways to detect radiations, but we present a non-invasive way of detecting them in real-time while an astronaut is in the mission. All Terrain Bio-nano (ATB) gear system is one such concept where we(More)
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