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Adders are one of the key components in arithmetic circuits. Enhancing their performance can significantly improve the quality of arithmetic designs. This is the reason why the theoretical lower bounds on the delay and area of an adder have been analysed, and circuits with performance close to these bounds have been designed. In this paper, we present a(More)
To better understand the pathogenesis of brain dysfunction in Gaucher disease (GD), we studied brain pathology in seven subjects with type 1 GD (four also exhibited parkinsonism and dementia), three with type 2 GD and four with type 3 GD. Unique pathologic patterns of disease involving the hippocampal CA2-4 regions and layer 4b of the calcarine cortex were(More)
The last decade has witnessed the emergence of the Application Specific Instruction-set Processor (ASIP) as a viable platform for embedded systems. Extensible ASIPs allow the user to augment a base processor with Instruction Set Extensions (ISEs) that execute on Application Specific Functional Units (AFUs)-dedicated hardware that executes the ISEs. Due to(More)
Erythropoietin (EPO) stimulates the growth of erythroblasts in the bone marrow (C. We report basal and hypoxia-stimulated expression of EPO and its receptor, EPOR, in human breast cancer cells, and we demonstrate EPO-stimulated tyrosine phosphorylation and the proliferation of these cells in vitro. In 50 clinical specimens of breast carcinoma, we report(More)
In the absence of conventional lymphatics, drainage of interstitial fluid and solutes from the brain parenchyma to cervical lymph nodes is along basement membranes in the walls of cerebral capillaries and tunica media of arteries. Perivascular pathways are also involved in the entry of CSF into the brain by the convective influx/glymphatic system. The(More)
Logic synthesis has made impressive progress in the last decade and has pervaded digital design replacing almost universally manual techniques. A remarkable exception is computer arithmetic and datapath design, where designers still rely mostly on well studied architectures; on datapaths, in most cases, logic synthesis plays at most a minor role in the(More)
Glucose metabolism in nervous tissue has been proposed to occur in a compartmentalized manner with astrocytes contributing largely to glycolysis and neurons being the primary site of glucose oxidation. However, mammalian astrocytes and neurons both contain mitochondria, and it remains unclear why in culture neurons oxidize glucose, lactate, and pyruvate to(More)
The increasing importance of datapath circuits in complex systems-on-chip calls for special arithmetic optimisations. The goal is to achieve automatically the handcrafted results which escape classic logic optimisations. Some work has been done in the recent years to infer the use of the carry-save representation in the synthesis of arithmetic circuits.(More)
RATIONALE Enhancement of histaminergic neurotransmission or histaminergic plus cholinergic neurotransmission may represent novel strategies for improving cognition in Alzheimer's disease. OBJECTIVE To evaluate the effects of a novel histamine H3 receptor inverse agonist (MK-3134), an acetylcholinesterase inhibitor (donepezil), and their combination in(More)