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Adders are one of the key components in arithmetic circuits. Enhancing their performance can significantly improve the quality of arithmetic designs. This is the reason why the theoretical lower bounds on the delay and area of an adder have been analysed, and circuits with performance close to these bounds have been designed. In this paper, we present a(More)
The last decade has witnessed the emergence of the Application Specific Instruction-set Processor (ASIP) as a viable platform for embedded systems. Extensible ASIPs allow the user to augment a base processor with Instruction Set Extensions (ISEs) that execute on Application Specific Functional Units (AFUs)-dedicated hardware that executes the ISEs. Due to(More)
To better understand the pathogenesis of brain dysfunction in Gaucher disease (GD), we studied brain pathology in seven subjects with type 1 GD (four also exhibited parkinsonism and dementia), three with type 2 GD and four with type 3 GD. Unique pathologic patterns of disease involving the hippocampal CA2-4 regions and layer 4b of the calcarine cortex were(More)
The increasing importance of datapath circuits in complex systems-on-chip calls for special arithmetic optimisations. The goal is to achieve automatically the handcrafted results which escape classic logic optimisations. Some work has been done in the recent years to infer the use of the carry-save representation in the synthesis of arithmetic circuits.(More)
In the absence of conventional lymphatics, drainage of interstitial fluid and solutes from the brain parenchyma to cervical lymph nodes is along basement membranes in the walls of cerebral capillaries and tunica media of arteries. Perivascular pathways are also involved in the entry of CSF into the brain by the convective influx/glymphatic system. The(More)
Logic synthesis has made impressive progress in the last decade and has pervaded digital design replacing almost universally manual techniques. A remarkable exception is computer arithmetic and datapath design, where designers still rely mostly on well studied architectures; on datapaths, in most cases, logic synthesis plays at most a minor role in the(More)
BACKGROUND The rapidly growing availability of diverse full genome sequences from across the world is increasing the feasibility of studying the large-scale population processes that underly observable pattern of virus diversity. In particular, characterizing the genetic structure of virus populations could potentially reveal much about how factors such as(More)
Glucose metabolism in nervous tissue has been proposed to occur in a compartmentalized manner with astrocytes contributing largely to glycolysis and neurons being the primary site of glucose oxidation. However, mammalian astrocytes and neurons both contain mitochondria, and it remains unclear why in culture neurons oxidize glucose, lactate, and pyruvate to(More)
The last decade has witnessed the emergence of the application-specific instruction-set processor (ASIP) as a viable platform for embedded systems. Extensible ASIPs allow the user to augment a base processor with instruction set extensions (ISEs) that execute on dedicated hardware application-specific functional units (AFUs). Due to the limited number of(More)