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The occurrence of stress and anxiety disorders has been closely associated with alterations of the amygdala GABAergic system. In these disorders, dysregulation of the serotonergic system, a very important modulator of the amygdala GABAergic system, is also well recognized. The present study, utilizing a learned helplessness stress rat model, was designed to(More)
Adders are one of the key components in arithmetic circuits. Enhancing their performance can significantly improve the quality of arithmetic designs. This is the reason why the theoretical lower bounds on the delay and area of an adder have been analysed, and circuits with performance close to these bounds have been designed. In this paper, we present a(More)
Neurological dysfunction caused by traumatic brain injury results in profound changes in net synaptic efficacy, leading to impaired cognition. Because excitability is directly controlled by the balance of excitatory and inhibitory activity, underlying mechanisms causing these changes were investigated using lateral fluid percussion brain injury in mice.(More)
To better understand the pathogenesis of brain dysfunction in Gaucher disease (GD), we studied brain pathology in seven subjects with type 1 GD (four also exhibited parkinsonism and dementia), three with type 2 GD and four with type 3 GD. Unique pathologic patterns of disease involving the hippocampal CA2-4 regions and layer 4b of the calcarine cortex were(More)
Since their first description as anomalous high affinity diazepam binding sites in rat peripheral tissues, the peripheral-type benzodiazepine receptor (PBR) has been increasingly studied to better understand nonneural effects of the benzodiazepines. The mammalian PBR is ubiquitously distributed with high concentrations in the outer mitochondrial membrane of(More)
The last decade has witnessed the emergence of the Application Specific Instruction-set Processor (ASIP) as a viable platform for embedded systems. Extensible ASIPs allow the user to augment a base processor with Instruction Set Extensions (ISEs) that execute on Application Specific Functional Units (AFUs)-dedicated hardware that executes the ISEs. Due to(More)
The peripheral-type benzodiazepine receptor is a site identified by its nanomolar affinity for [3H]diazepam, similar to the affinity of diazepam for the central-type benzodiazepine receptor in the brain. The peripheral-type benzodiazepine receptor occurs in many peripheral tissues but has discrete localizations as indicated by autoradiographic studies(More)
In the absence of conventional lymphatics, drainage of interstitial fluid and solutes from the brain parenchyma to cervical lymph nodes is along basement membranes in the walls of cerebral capillaries and tunica media of arteries. Perivascular pathways are also involved in the entry of CSF into the brain by the convective influx/glymphatic system. The(More)
Logic synthesis has made impressive progress in the last decade and has pervaded digital design replacing almost universally manual techniques. A remarkable exception is computer arithmetic and datapath design, where designers still rely mostly on well studied architectures; on datapaths, in most cases, logic synthesis plays at most a minor role in the(More)
BACKGROUND The rapidly growing availability of diverse full genome sequences from across the world is increasing the feasibility of studying the large-scale population processes that underly observable pattern of virus diversity. In particular, characterizing the genetic structure of virus populations could potentially reveal much about how factors such as(More)