Author pages are created from data sourced from our academic publisher partnerships and public sources.
Relationship of semicircular canal size to vestibular-nerve afferent sensitivity in mammals.
The relationship between semicircular canal radius of curvature and afferent sensitivity has not been experimentally determined. We characterized mouse semicircular canal afferent responses to… Expand
A role for bradykinin in the development of anti-collagen antibody-induced arthritis.
OBJECTIVES Clinical and experimental observations have suggested that bradykinin, a major activation product of the plasma kallikrein-kinin system, is involved in the pathogenesis of arthritis, but… Expand
High Molecular Weight Kininogen Binds Phosphatidylserine and Opsonizes Urokinase Plasminogen Activator Receptor–Mediated Efferocytosis
Phagocytosis of apoptotic cells (efferocytosis) is essential for regulation of immune responses and tissue homeostasis and is mediated by phagocytic receptors. In this study, we found that urokinase… Expand
An essential role of high-molecular-weight kininogen in endotoxemia
- Aizhen Yang, Z. Xie, B. Wang, R. Colman, J. Dai, Yi Wu
- The Journal of experimental medicine
- 4 September 2017
In this study, we show that mice lacking high-molecular-weight kininogen (HK) were resistant to lipopolysaccharide (LPS)-induced mortality and had significantly reduced circulating LPS levels.… Expand
Role of plasma kallikrein-kinin system activation in synovial recruitment of endothelial progenitor cells in experimental arthritis.
OBJECTIVE To examine whether activation of the plasma kallikrein-kinin system (KKS) mediates synovial recruitment of endothelial progenitor cells (EPCs) in arthritis. METHODS EPCs were isolated… Expand
The Procoagulant Activity of Apoptotic Cells Is Mediated by Interaction with Factor XII
Apoptotic cells, by externalizing phosphatidylserine (PS) as a hallmark feature, are procoagulant. However, the mechanism by which apoptotic cells activate coagulation system remains unknown.… Expand
A critical role for plasma kallikrein in the pathogenesis of autoantibody‐induced arthritis
- Aizhen Yang, J. Zhou, +4 authors Yi Wu
- Biology, Medicine
- FASEB journal : official publication of the…
- 14 August 2017
The plasma kallikrein‐kinin system (KKS) consists of serine proteases, prekallikrein (pKal) and factor XII (FXII), and a cofactor, high‐MW kininogen (HK). Upon activation, activated pKal and FXII… Expand
The Plasma Kallikrein–Kininogen Pathway Is Critical in the Pathogenesis of Colitis in Mice
The kallikrein–kinin system (KKS) consists of two serine proteases, prekallikrein (pKal) and factor XII (FXII), and a cofactor, high-molecular-weight kininogen (HK). Upon activation of the KKS, HK is… Expand
Plasma kallikrein contributes to ambient particulate matter-induced lung injury.
- B. Wang, Xiaofeng Yan, Fengwu Chen, Aizhen Yang, Y. Lu, Y. Wu
- Biology, Medicine
- Biochemical and biophysical research…
- 20 October 2019
Particulate matter (PM) is a key component of air pollutants and is associated with mortality of cardiovascular and respiratory diseases. PM-induced tissue injury involves inflammation and… Expand
Hydrocyanation of 2-arylmethyleneindan-1,3-diones using potassium hexacyanoferrate(II) as a nontoxic cyanating agent
Abstract The hydrocyanation of 2-arylmethyleneindan-1,3-diones with potassium hexacyanoferrate(II) as a nontoxic cyanating agent to synthesize 2-(1,3-dioxoindan-2-yl)-2-arylacetonitriles in the… Expand