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Relationship of semicircular canal size to vestibular-nerve afferent sensitivity in mammals.
The relationship between semicircular canal radius of curvature and afferent sensitivity has not been experimentally determined. We characterized mouse semicircular canal afferent responses toExpand
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A role for bradykinin in the development of anti-collagen antibody-induced arthritis.
OBJECTIVES Clinical and experimental observations have suggested that bradykinin, a major activation product of the plasma kallikrein-kinin system, is involved in the pathogenesis of arthritis, butExpand
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High Molecular Weight Kininogen Binds Phosphatidylserine and Opsonizes Urokinase Plasminogen Activator Receptor–Mediated Efferocytosis
Phagocytosis of apoptotic cells (efferocytosis) is essential for regulation of immune responses and tissue homeostasis and is mediated by phagocytic receptors. In this study, we found that urokinaseExpand
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An essential role of high-molecular-weight kininogen in endotoxemia
In this study, we show that mice lacking high-molecular-weight kininogen (HK) were resistant to lipopolysaccharide (LPS)-induced mortality and had significantly reduced circulating LPS levels.Expand
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Role of plasma kallikrein-kinin system activation in synovial recruitment of endothelial progenitor cells in experimental arthritis.
OBJECTIVE To examine whether activation of the plasma kallikrein-kinin system (KKS) mediates synovial recruitment of endothelial progenitor cells (EPCs) in arthritis. METHODS EPCs were isolatedExpand
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The Procoagulant Activity of Apoptotic Cells Is Mediated by Interaction with Factor XII
Apoptotic cells, by externalizing phosphatidylserine (PS) as a hallmark feature, are procoagulant. However, the mechanism by which apoptotic cells activate coagulation system remains unknown.Expand
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A critical role for plasma kallikrein in the pathogenesis of autoantibody‐induced arthritis
  • Aizhen Yang, J. Zhou, +4 authors Yi Wu
  • Biology, Medicine
  • FASEB journal : official publication of the…
  • 14 August 2017
The plasma kallikrein‐kinin system (KKS) consists of serine proteases, prekallikrein (pKal) and factor XII (FXII), and a cofactor, high‐MW kininogen (HK). Upon activation, activated pKal and FXIIExpand
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The Plasma Kallikrein–Kininogen Pathway Is Critical in the Pathogenesis of Colitis in Mice
The kallikrein–kinin system (KKS) consists of two serine proteases, prekallikrein (pKal) and factor XII (FXII), and a cofactor, high-molecular-weight kininogen (HK). Upon activation of the KKS, HK isExpand
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Plasma kallikrein contributes to ambient particulate matter-induced lung injury.
Particulate matter (PM) is a key component of air pollutants and is associated with mortality of cardiovascular and respiratory diseases. PM-induced tissue injury involves inflammation andExpand
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Hydrocyanation of 2-arylmethyleneindan-1,3-diones using potassium hexacyanoferrate(II) as a nontoxic cyanating agent
Abstract The hydrocyanation of 2-arylmethyleneindan-1,3-diones with potassium hexacyanoferrate(II) as a nontoxic cyanating agent to synthesize 2-(1,3-dioxoindan-2-yl)-2-arylacetonitriles in theExpand
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