Aisling Dunne

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Interleukin-1 (IL-1) lies at the center of the inflammatory response. This pro-inflammatory cytokine was first pinned down for its ability to induce fever, and was later assigned additional biological functions including neutrophil recruitment, lymphocyte activation and induction of inflammatory mediators 1. Excessive production of IL-1β drives the(More)
The detection of nucleic acids by the innate immune system is an essential host response during viral infection. In recent years, a number of immune sensors capable of recognizing cytosolic DNA have been identified and include the PYHIN family members AIM2, IFI16, and p204 as well as the enzyme, cGAS. Activation of these receptors leads to the induction of(More)
BACKGROUND Osteoarthritis (OA) is a chronic debilitating joint disorder of particularly high prevalence in the elderly population. Intra-articular basic calcium phosphate (BCP) crystals are present in the majority of OA joints and are associated with severe degeneration. They are known to activate macrophages, synovial fibroblasts, and articular(More)
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