Aishwarya Sreenivasan

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Disruption of functional connectivity between brain regions may represent an early functional consequence of β-amyloid pathology prior to clinical Alzheimer's disease. We aimed to investigate if non-demented older individuals with increased amyloid burden demonstrate disruptions of functional whole-brain connectivity in cortical hubs (brain regions(More)
BACKGROUND Previous studies have revealed that functional magnetic resonance imaging (fMRI) blood oxygen level-dependent (BOLD) signal in specific brain regions correlates with cross-sectional performance on standardized clinical trial measures in Alzheimer's disease (AD); however, the relationship between longitudinal change in fMRI-BOLD signal and(More)
OBJECTIVE To examine the feasibility and test-retest reliability of encoding-task functional magnetic resonance imaging (fMRI) in mild Alzheimer disease (AD). DESIGN Randomized, double-blind, placebo-controlled study. SETTING Memory clinical trials unit. PARTICIPANTS We studied 12 patients with mild AD (mean [SEM] Mini-Mental State Examination score,(More)
The Harvard community has made this article openly available. Please share how this access benefits you. Your story matters. disconnection of cortical hubs in non-demented subjects with elevated amyloid burden. Disruption of functional connectivity between brain regions may represent an early functional consequence of b-amyloid pathology prior to clinical(More)
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