Genetic testing for risk of depression requires a reconsideration of ethical issues in genetics and how they manifest in psychiatric practice. A precautionary approach is advocated in that there should be limits on the use of the 5-HTT genetic test until its clinical utility and broader social impact are better understood.
Genomic testing has reached the point where, technically at least, it can be cheaper to undertake panel-, exome- or whole genome testing than it is to sequence a single gene. An attribute of these approaches is that information gleaned will often have uncertain significance. In addition to the challenges this presents for pre-test counseling and informed… (More)
Engineering and Medicine recently provided conditional endorsement for mitochondrial transfer. While its approach is more conservative in some respects than that of the United Kingdom (which passed its own regulations in 2015), it marks a significant policy development for a potentially large implementer of this emerging intervention. In this perspective,… (More)
BACKGROUND Personalized genomic risk information has the potential to motivate behaviour change and promote population health, but the success of this will depend upon effective risk communication strategies. OBJECTIVE To determine preferences for different graphical and written risk communication formats, and the delivery of genomic risk information… (More)
Genomic testing is rapidly becoming established in clinical practice and research. In this paper we consider the ethical issues arising in genomic testing in children, focusing on the clinical context. After describing how genomics can be said to depart from genetics in ethically relevant ways, we introduce two case studies involving ethical issues in… (More)
1. This paper discusses scientific, ethical and governance aspects of genome editing with engineered nucleases. First, the scientific state of the art for three major genome editing techniques and their current applications in humans, animals and plants are discussed. Ethical concepts and issues arising from these technologies are then identified. The next… (More)
1 This paper outlines the current state of the art, future developments and main ethical issues that arise in the context of genomics, health records, database linkage and privacy. Current oversight and potential questions that might need to be addressed are highlighted.