Aimin Ji

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Long noncoding RNAs (lncRNAs) have been attracting immense research interest, while only a handful of lncRNAs have been characterized thoroughly. Their involvement in the fundamental cellular processes including regulate gene expression at epigenetics, transcription, and post-transcription highlighted a central role in cell homeostasis. However, lncRNAs(More)
Long non-coding RNAs (lncRNAs) are series of transcripts with important biological functions. Various diseases have been associated with aberrant expression of lncRNAs and the related dysregulation of mRNAs. In this review, we highlight the mechanisms of dynamic lncRNA expression. The chromatin state contributes to the low and specific expression of(More)
RNAi technology is taking strong position among the key therapeutic modalities, with dozens of siRNA-based programs entering and successfully progressing through clinical stages of drug development. To further explore potentials of RNAi technology as therapeutics, we engineered and tested VEGFR2 siRNA molecules specifically targeted to tumors through(More)
The clinical application of small interfering RNA (siRNA) has been restricted by their poor intracellular uptake, low serum stability, and inability to target specific cells. During the last several decades, a great deal of effort has been devoted to exploring materials for siRNA delivery. In this study, biodegradable, tumor-targeted, self-assembled peptide(More)
In this paper, a mixed-model assembly system is modeled using ATPN (agent oriented timed Petri net) based on assembly resources classification. Firstly, the basic concepts and definition of ATPN is described. Secondly, with ATPN method introduced into mixed-model system research the modeling of a mixed-model assembly system is discussed. The development of(More)
The original paper of this article unfortunately contains mistakes. In Fig. 4c, the northern blot analysis validated the size of the lncRNA-N1LR. When we performed the northern blot analysis , all the RNA bands from different samples appeared to be in the same size, which were consistent with the result of the RACE. However, in these results, there was a(More)
In recent years, long noncoding RNAs (lncRNAs) have been shown to have critical roles in a broad range of cell biological processes. However, the activities of lncRNAs during ischemic stroke remain largely unknown. In this study, we carried out a genome-wide lncRNA microarray analysis in rat brains with ischemia/reperfusion (I/R) injury. The results(More)
The modeling of the functional model has been researched by using case-based reasoning (CBR) in conceptual design. On the basis of the describing of the functional model and the coding of the product functionthe functional nodes and the edge have been matched. The functional model which has the most high similarity has been searchedthen the nodes and edges(More)
α-Lipoic acid (ALA) is known as a powerful antioxidant, which has been reported to have protective effects against various cardiovascular diseases. The present study aimed to determine whether ALA pre- or post-treatment induced protective effects against hypoxia/reoxygenation-induced injury via inhibition of apoptosis and autophagy in human umbilical vein(More)
According to the existing problems in the development of actual product and working process of excavator working device's boom, the method of integrated design and analysis for excavator boom is put forward. The defects in the process of CAD/CAE integration are summarized, the integrated design and analysis system including parametric design of boom,(More)