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NFATc1 is an important transcription factor which is critical for lineage selection in T-cell differentiation, cardiac valve morphogenesis, lymphatic endothelial development, osteoblast differentiation and osteoclastogenesis. Especially, it is a master regulator of RANKL-induced osteoclast differentiation and plays a pivotal role in osteoclast fusion and(More)
CLC-7 is a member of the voltage-gated chloride channels family. It resides mainly in the late endosomes, lysosomes and the ruffled membrane of osteoclasts. Mice deficient in the ubiquitously expressed ClC-7 Cl(-) channel show severe osteopetrosis and retinal degeneration. In the present review, some of the known features of CLC-7 such as structure,(More)
The crystal structure of the title co-crystal, C(12)H(9)N(3)·C(5)H(8)O(4), N-H⋯O and O-H⋯N hydrogen bonds link the components. There are also π-π stacking inter-actions between the imidazole rings, between the imidazole and pyridine rings and between the pyridine and benzene rings [centroid-centroid distances = 3.643 (2), 3.573 (2) and 3.740 (1)Å,(More)
In the title compound, C(19)H(13)N(5)·C(4)H(8)O(2)·2H(2)O, the mol-ecular skeleton of the 2,6-bis-(benzimidazol-2-yl)pyridine (bbip) mol-ecule is essentially planar (r.m.s. deviation = 0.023 Å). An extensive three-dimensional network of inter-molecular N-H⋯O, O-H⋯O and O-H⋯N hydrogen bonds consolidates the crystal packing, which also exhibits π-π(More)
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