RATIONALE Recreational drug use peaks in the developmental stage of adolescence, and exposure to drugs during adolescence may predict drug dependence in adulthood. Nevertheless, adolescent drug vulnerability is not widely studied in animal models of drug intake, and very few studies have investigated sex differences in drug-related behavior during… (More)
The platelet monoamine oxidase activity (MAO) of 33 patients with epilepsy was compared with a group of neurological patients and a group of normal control subjects. We found that the MAO activity was increased significantly in the epileptic group when compared with the normal. This was not related to anticonvulsant medication. These results could be… (More)
Thirty drug-resistant epilepsy patients were given 20-30 mg of clobazam in addition to their other anticonvulsants and followed up for 2-3 years in an open-ended study. Fit frequency was markedly reduced in 43% of patients, few side effects occurred and psychological parameters including the Crown-Crisp questionnaire, showed improvement. It therefore seems… (More)
Twenty four patients with drug resistant epilepsy were given lorazepam and placebo added to their pre-existing drug regime. With lorazepam there was a significant reduction in seizures, especially in those with focal and partial complex attacks. The drug proved effective whether or not the patients regarded stress as a trigger to their seizures, but on the… (More)
The averaged visual evoked potentials of 10 normal subjects were studied either with eyes fixated while a chequerboard reversed or when they moved their eyes across the stationary chequerboard. The resulting occipital potentials averaged using a computer of averaged transients were discrepant for the 2 conditions. The latency of the P100 component was… (More)
Benzodiazepines given intravenously abort status epilepticus, and abolish paroxysmal EEG discharges. The study reported concerns the effect of small doses (about 1 mg) of lorazepam on these EEG changes, assessed visually, in the resting record, as well as during overbreathing and photic stimulation. Thirty patients were examined, approximately half had… (More)
Oral tyramine activated pre-existing episodic EEG abnormalities--namely, sharp waves, spike and wave, and localised theta activity--in epileptic patients. Little change was found in the EEGs of migrainous subjects after chocolate or beta-phenylethylamine. The implications of the findings with tyramine are discussed.