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Shiga toxin 2-induced intestinal pathology in infant rabbits is A-subunit dependent and responsive to the tyrosine kinase and potential ZAK inhibitor imatinib
Shiga toxin producing Escherichia coli (STEC) are a major cause of food-borne illness worldwide. However, a consensus regarding the role Shiga toxins play in the onset of diarrhea and hemorrhagicExpand
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Absence of Nicotinamide Nucleotide Transhydrogenase in C57BL/6J Mice Exacerbates Experimental Atherosclerosis
Background: Mitochondrial reactive oxygen species (ROS) contribute to inflammation and vascular remodeling during atherosclerotic plaque formation. C57BL/6N (6N) and C57BL/6J (6J) mice displayExpand
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AAV8-mediated overexpression of mPCSK9 in liver differs between male and female mice.
BACKGROUND AND AIMS The recombinant adeno-associated viral vector serotype 8 expressing the gain-of-function mutation of mouse proprotein convertase subtilisin/kexin type 9 (AAV8- PCSK9) is a newExpand
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Natural killer T (NKT) cells accelerate Shiga toxin type 2 (Stx2) pathology in mice
Shiga toxin-producing Escherichia coli (STEC) is a leading cause of childhood renal disease Hemolytic Uremic Syndrome (HUS). The involvement of renal cytokines and chemokines is suspected to play aExpand
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Macrophage-Associated Lipin-1 Enzymatic Activity Contributes to Modified Low-Density Lipoprotein–Induced Proinflammatory Signaling and Atherosclerosis
Objective— Macrophage proinflammatory responses induced by modified low-density lipoproteins (modLDL) contribute to atherosclerotic progression. How modLDL causes macrophages to becomeExpand
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Lipin-1 contributes to modified low-density lipoprotein-elicited macrophage pro-inflammatory responses.
Atherosclerosis is a chronic inflammatory disease of large and medium-sized arteries and the underlying cause of cardiovascular disease, a major cause of mortality worldwide. The over-accumulation ofExpand
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Abstract 608: Macrophage-Associated Lipin-1 Contributes to Atherosclerosis
Objective: Macrophage pro-inflammatory responses induced by oxidized low-density lipoproteins (oxLDL) mediate atherosclerosis progression. However, how oxLDL causes macrophages to become pro-inflam...
Abstract 382: Lipin-1 Links Pro-inflammatory Responses and Foam Cell Formation by Oxidized-Low Density Lipoprotein-Elicited Macrophages
Atherosclerosis is a chronic inflammatory disease of large and medium-sized arteries and one of the underlying causes of cardiovascular disease (CVD). Macrophages participate decisively in theExpand