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AIM To identify patient-reported outcome measures (PROMs) specifically developed and used to assess the impact of ophthalmic disorders in children and to systematically assess their quality as a basis for recommendations about their use in clinical and research settings. METHODS A systematic review of the literature was performed in MEDLINE, EMBASE,(More)
The use of nitrate-contaminated drinking water to prepare infant formula is a well-known risk factor for infant methemoglobinemia. Affected infants develop a peculiar blue-gray skin color and may become irritable or lethargic, depending on the severity of their condition. The condition can progress rapidly to cause coma and death if it is not recognized and(More)
OBJECTIVE To describe the cytopathological method used in the analysis of vitreous samples in the diagnosis of primary intraocular lymphoma (PIOL). PARTICIPANTS Seven patients with refractory posterior uveitis referred to a regional ocular inflammatory service were diagnosed as having PIOL between 1999 and 2006. METHODS Clinical features of the uveitis(More)
OBJECTIVES To investigate a cluster of leukaemia among young people and assess the plausibility of a disease-exposure relationship. DESIGN Descriptive analysis of population-based leukaemia incidence data, review of evidence related to the causation of leukaemia, assessment of environmental exposures to known leukaemogens, and resulting risks of(More)
A. ANALYSIS OF NASALIZED VOWELS In a previous report (1), a theoretical explanation of the spectral structure of nasal-ized vowels was given, and rules that govern the locations of formants and antiformants were described. An experimental study has been performed on vowels of this type, with the use of a computer program and speech materials reported on(More)
been recognized that formant transitions constitute important cues for the recognition of initial voiced stop consonants. Some generally accepted rules concerning the formant transitions associated with different consonants have emerged from these studies, but there are considerable areas of disagreement. We have carried out a series of speech-synthesis(More)
BACKGROUND Effective managed care requires the active participation of health professionals and patients alike. The essential elements in management of diabetes involve well-defined professional clinical protocols, adequate patient education, and adherence to these management guidelines by all parties. This study was designed to evaluate how well the(More)
BACKGROUND Understanding children's views about living with congenital heart defects (CHDs) is fundamental to supporting their successful participation in daily life, school and peer relationships. As an adjunct to a health and quality of life outcomes questionnaire, we asked school-age children who survived infant heart procedures to describe their(More)
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