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  • Aik Jiang Lau, Guixiang Yang, Ganesh Rajaraman, Christie C. Baucom, Thomas K. H. Chang
  • Medicine, Chemistry
  • Journal of Pharmacology and Experimental…
  • 2010 (First Publication: 1 December 2010)
  • Ginkgo biloba extract activates pregnane X receptor (PXR), but how this occurs is not known. Therefore, we investigated the mechanism of PXR activation by the extract and the role of five individualExpand
  • Devinder Jeet Sharma, Aik Jiang Lau, Matthew A. Sherman, Thomas K. H. Chang
  • Chemistry, Medicine
  • Biochemical pharmacology
  • 2013 (First Publication: 1 June 2013)
  • Rilpivirine and etravirine are second generation non-nucleoside reverse transcriptase inhibitors approved recently by the United States Food and Drug Administration for the treatment of humanExpand
  • Aik Jiang Lau, Guixiang Yang, Ganesh Rajaraman, Christie C. Baucom, Thomas K. H. Chang
  • Medicine, Chemistry
  • Journal of Pharmacology and Experimental…
  • 2011 (First Publication: 1 March 2011)
  • Conflicting data exist as to whether meclizine is an activator of human pregnane X receptor (hPXR). Therefore, we conducted a detailed, systematic investigation to determine whether meclizine affectsExpand
  • Aik Jiang Lau, Thomas K. H. Chang
  • Chemistry, Medicine
  • British journal of pharmacology
  • 2013 (First Publication: 1 September 2013)
  • BACKGROUND AND PURPOSE Naturally occurring splice variants of human CAR (hCAR), including hCAR-SV23 (insertion of amino acids SPTV) and hCAR-SV24 (APYLT), have been shown to be expressed in liver.Expand
  • Jiarong Xie, Nur Fazilah Saburulla, +4 authors Aik Jiang Lau
  • Chemistry, Medicine
  • Drug Metabolism and Disposition
  • 2019 (First Publication: 1 January 2019)
  • The present study investigated the contribution of microsomal cytochrome P450 and cytosolic aldehyde oxidase-1 (AOX-1) to carbazeran 4-oxidation and O6-benzylguanine 8-oxidation in human liverExpand
  • Aik Jiang Lau, Guixiang Yang, Thomas K. H. Chang
  • Medicine, Chemistry
  • Journal of Pharmacology and Experimental…
  • 2011 (First Publication: 1 November 2011)
  • Naturally occurring splice variants of human constitutive androstane receptor (hCAR) exist, including hCAR-SV23 (insertion of amino acids SPTV), hCAR-SV24 (APYLT), and hCAR-SV25 (SPTV and APYLT). AnExpand
  • Aik Jiang Lau, Thomas K. H. Chang
  • Medicine, Chemistry
  • Toxicology and applied pharmacology
  • 2014 (First Publication: 1 June 2014)
  • The naturally occurring SV23 splice variant of human constitutive androstane receptor (hCAR-SV23) is activated by di-(2-ethylhexyl)phthalate (DEHP), which is detected as a contaminant in fetal bovineExpand