Aijie Liu

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Synthesis of chloroquine analogues Chloroquine (CQ) analogues with side alkyl amino side chain variation were synthesized via substitution reaction of an appropriate amine and 4,7-dichloroquinoline. 1 CQ analogues of ring-size variations and ring-substituent variations were synthesized similarly using an appropriate quinoline or pyridine derivative as(More)
The majority of children with Dravet syndrome (DS) are caused by de novo SCN1A mutations. To investigate the origin of the mutations, we developed and applied a new method that combined deep amplicon resequencing with a Bayesian model to detect and quantify allelic fractions with improved sensitivity. Of 174 SCN1A mutations in DS probands which were(More)
The mammalian (mechanistic) target of rapamycin (mTOR) regulates critical immune processes that remain incompletely defined. Interest in mTOR inhibitor drugs is heightened by recent demonstrations that the mTOR inhibitor rapamycin extends lifespan and healthspan in mice. Rapamycin or related analogues (rapalogues) also mitigate age-related debilities(More)
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