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We describe here the design and initial implementation of the eMERGE-PGx project. eMERGE-PGx, a partnership of the Electronic Medical Records and Genomics Network and the Pharmacogenomics Research Network, has three objectives: (i) to deploy PGRNseq, a next-generation sequencing platform assessing sequence variation in 84 proposed pharmacogenes, in nearly(More)
Primary care in the United States has been in the midst of a transformation from a system based solely on individual office interactions to one that includes managing health at a population level. The chronic care model provides a robust framework for health systems to transform and restructure their delivery of care to one that is committed to delivering(More)
Implementation of pharmacogenetic-guided warfarin dosing has been hindered by inconsistent results from reported clinical trials and a lack of available algorithms that include alleles prevalent in non-white populations. However, current evidence indicates that algorithm-guided dosing is more accurate than empirical dosing. To facilitate multiethnic(More)
For almost 50 years, the Icahn School of Medicine at Mount Sinai has continually invested in genetics and genomics, facilitating a healthy ecosystem that provides widespread support for the ongoing programs in translational pharmacogenomics. These programs can be broadly cataloged into discovery, education, clinical implementation and testing, which are(More)
The term autosomal recessive congenital ichthyosis (ARCI) refers to a group of rare disorders of keratinization classified as nonsyndromic forms of ichthyosis. This group was traditionally divided into lamellar ichthyosis (LI) and congenital ichthyosiform erythroderma (CIE) but today it also includes harlequin ichthyosis, self-healing collodion baby, acral(More)
There is widespread agreement by many professional societies, consumer groups, public policy advisers, and health plans that primary-care providers will be major drivers behind changes in healthcare delivery. Primary-care providers comprise mostly general internists, pediatricians, family physicians, and nonphysician providers. Studies suggest that(More)
a Servicio de Dermatología, Hospital Infantil Niño Jesús, Madrid, Spain b Servicio de Dermatología, Hospital La Paz, Madrid, Spain c Servicio de Anatomía Patológica, Hospital Infantil Niño Jesús, Madrid, Spain d Unidad de Medicina Molecular, Departamento de Medicina e Instituto de Biología Molecular y Celular del Cáncer, Universidad de Salamanca, Salamanca,(More)
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