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Co-occupancy by multiple cardiac transcription factors identifies transcriptional enhancers active in heart
Identification of genomic regions that control tissue-specific gene expression is currently problematic. ChIP and high-throughput sequencing (ChIP-seq) of enhancer-associated proteins such as p300Expand
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  • Open Access
Polycomb Repressive Complex 2 Regulates Normal Development of the Mouse Heart
Rationale: Epigenetic marks are crucial for organogenesis, but their role in heart development is poorly understood. Polycomb repressive complex 2 (PRC2) trimethylates histone H3 at lysine 27, whichExpand
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  • Open Access
Overexpression of micro ribonucleic acid 29, highly up-regulated in diabetic rats, leads to insulin resistance in 3T3-L1 adipocytes.
Micro-RNAs (miRNAs) have been suggested to play pivotal roles in multifarious diseases associated with the posttranscriptional regulation of protein-coding genes. In this study, we aimed toExpand
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MicroRNA-1 Negatively Regulates Expression of the Hypertrophy-Associated Calmodulin and Mef2a Genes
ABSTRACT Calcium signaling is a central regulator of cardiomyocyte growth and function. Calmodulin is a critical mediator of calcium signals. Because the amount of calmodulin within cardiomyocytes isExpand
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  • Open Access
PRC2 directly methylates GATA4 and represses its transcriptional activity.
Polycomb-repressive complex 2 (PRC2) promotes tissue-specific differentiation by depositing trimethylated histone H3 Lys 27 (H3K27me3) epigenetic marks to silence ectopic gene expression programs.Expand
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Interrogating translational efficiency and lineage-specific transcriptomes using ribosome affinity purification
  • P. Zhou, Y. Zhang, +8 authors W. Pu
  • Medicine, Biology
  • Proceedings of the National Academy of Sciences
  • 3 September 2013
Significance We developed reagents and approaches to pull down ribosome-associated RNAs from Cre-labeled cells. We show that this strategy is useful to probe cell type-specific gene expression andExpand
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  • Open Access
Derivation of Pluripotent Stem Cells with In Vivo Embryonic and Extraembryonic Potency
Of all known cultured stem cell types, pluripotent stem cells (PSCs) sit atop the landscape of developmental potency and are characterized by their ability to generate all cell types of an adultExpand
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Modeling the mitochondrial cardiomyopathy of Barth syndrome with iPSC and heart-on-chip technologies
Study of monogenic mitochondrial cardiomyopathies may yield insights into mitochondrial roles in cardiac development and disease. Here, we combined patient-derived and genetically engineered inducedExpand
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  • Open Access
Dynamic GATA4 enhancers shape the chromatin landscape central to heart development and disease
How stage-specific enhancer dynamics modulate gene expression patterns essential for organ development, homesostasis, and disease is not well understood. Here, we addressed this question by mappingExpand
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  • Open Access
Regulation of GATA4 transcriptional activity in cardiovascular development and disease.
Transcription factors regulate formation and function of the heart, and perturbation of transcription factor expression and regulation disrupts normal heart structure and function. MultipleExpand
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  • Open Access