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Reduced aquaporin3 expression and survival of keratinocytes in the depigmented epidermis of vitiligo.
The results of immunoprecipitation and double staining confirmed colocalization of AQP3 with E-cadherin, as well as an active role of AQp3 in E- cadherIn expression of cell-to-cell contacts and induced no increase in differentiating markers at high calcium concentrations and reduced survival of KCs, suggesting that reduced AQP 3 in vitiliginous KCs might be responsible for their reduced survival. Expand
Genetic polymorphism of cytochrome P450 2C9 in diphenylhydantoin-induced cutaneous adverse drug reactions
A CYP2C9*3 variant could play a role in the proportion of patients with DPH-induced CADRs that differ from patients withDPH- induced CADRs showing positive patch-test results, as well as in the patients with positivePatch testing reactions to DPH differed from those with the CYP1C9-3 polymorphism. Expand
Developing core outcome set for vitiligo clinical trials: international e‐Delphi consensus
The aim of this work is to provide a database of existing and prospective cases of Dermatology-related cancers and to establish a baseline for the development of new drugs and treatments for these conditions. Expand
Stem cell factor induces ERM proteins phosphorylation through PI3K activation to mediate melanocyte proliferation and migration
It is demonstrated that SCF‐induced ERM proteins phosphorylation on threonine residue and Rac1 activation in cultured normal human melanocytes through the activation of PI3K indicates that phosphorylated‐ERM proteins plays an important role in the regulation of SCf‐induced melanocyte proliferation and migration. Expand
Fragrance contact dermatitis in Korea: a joint study
It is concluded that including additional fragrance allergens may be useful for the detection of fragrance allergy. Expand
Cadherin 11, a miR-675 target, induces N-cadherin expression and epithelial-mesenchymal transition in melasma.
The data indicate that CDH11 in fibroblasts and keratinocytes is a target of miR-675, and could be involved in melanogenesis through the induction of N-cadherin during epithelial-mesenchymal transition. Expand
An updated review of melasma pathogenesis
The role of paracrine factors from dermal fibroblasts, such as stem cell factor and Wnt inhibitory factor-1 (WIF-1), is elucidated in melasma and the involvement of ion exchangers and microRNAs (miRNAs), such as H19 miRNA (miR-675), are also suggested. Expand
Less keratinocyte-derived factors related to more keratinocyte apoptosis in depigmented than normally pigmented suction-blistered epidermis may cause passive melanocyte death in vitiligo.
Lower expression of keratinocyte-derived factors, including SCF, in vitiliginous keratinocytes, which could result from keratin cell apoptosis, might be responsible for passive melanocyte death and may explain the Koebner phenomenon. Expand
Treatment of Palmar Hyperhidrosis with Tap Water Iontophoresis: A Randomized, Sham-Controlled, Single-Blind, and Parallel-Designed Clinical Trial
Tap water iontophoresis could be used as an effective and safe treatment modality for palmar hyperhidrosis with a randomized, sham-controlled, single-blind, and parallel-designed study. Expand
Role of Keratinocytes in the Development of Vitiligo
  • Ai-Young Lee
  • Biology, Medicine
  • Annals of dermatology
  • 26 April 2012
The results of a comparison between depigmented and normally pigmented epidermis in patients with vitiligo showed that the keratinocytes in the depigments were more vulnerable to apoptosis, resulting in passive melanocyte death. Expand