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Synaptophysin (SYP) is a synaptic vesicle membrane protein and involved in the release of neurotransmitters, synaptic plasticity, and formation and recycling of synaptic vesicles. SYP may serve as a specific marker of synaptic proteins. Our results showed high glucose and hypoxia could significantly impair the intelligence and the SYP level was positively(More)
BACKGROUND The clinical effect of cerebral microbleeds (CMBs) on cognition has been receiving much research attention, but results are often inconsistent. MATERIAL/METHODS We searched PubMed, Embase, Web of Science, and some Chinese electronic databases. A total of 15 studies were included. RESULTS Patients with CMBs had higher incidence of cognitive(More)
BACKGROUND Leukoaraiosis, microbleeds, and silent brain infarctions are phenotypes of small vessel disease. Leukoaraiosis is the most prevalent, and advanced periventricular leukoaraiosis is regarded as a strong predictor of cognitive dysfunction. Microbleeds and silent brain infarctions sometimes coexist with leukoaraiosis. This study aims to analyze the(More)
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