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A common BIM deletion polymorphism mediates intrinsic resistance and inferior responses to tyrosine kinase inhibitors in cancer
Tyrosine kinase inhibitors (TKIs) elicit high response rates among individuals with kinase-driven malignancies, including chronic myeloid leukemia (CML) and epidermal growth factor receptor–mutated… Expand
Acquired factor V inhibitor. A problem-based systematic review.
Acquired factor V(FV) inhibitors as a rare bleeding disorder, poses a formidable challenge to treating physicians with limited evidence to guide its management. We systematically reviewed our… Expand
Prevalence of Low Bone Mass and Vitamin D Deficiency in β-Thalassemia Major
Abstract Low bone mass, a major cause of morbidity in patients with β-thalassemia major (β-TM), is multifactorial. There is lack of data about the current prevalence of low bone mass in patients with… Expand
Treatment of severe neutropenic sepsis with granulocyte transfusion in the current era--experience from an adult haematology unit in Singapore.
OBJECTIVES Granulocyte transfusion's (GT) efficacy among adult severe neutropenic sepsis (SNS) patients remains uncertain. We assessed GT's efficacy and its determinants among SNS patients in an… Expand
Prevention of transfusion-transmitted cytomegalovirus (CMV) infection: Standards of care.
L. Lieberman, D. V. Devine, H. W. Reesink, S. Panzer, J. Wong, T. Raison, S. Benson, J. Pink, G. C. Leitner, M. Horvath, V. Compernolle, P. S. Prado Scuracchio, S. Wendel, G. Delage, S. Nahirniak, X.… Expand
The M351T BCR-ABL Kinase Mutation Is Uncommon in Asian Patients with Imatinib-Resistant Chronic Myeloid Leukemia: Possible Relationship with Imatinib Plasma Levels.
To date, more than 50 BCR-ABL kinase domain mutations have been described in patients with imatinib-resistant (IM-R) chronic myeloid leukemia (CML) and 66% of these reported cases have mutations… Expand
International Validation of a Dithiothreitol (DTT)-Based Method to Resolve the Daratumumab Interference with Blood Compatibility Testing
Introduction Daratumumab (DARA), an IgG1k human monoclonal antibody (Ab) against CD38, is a promising novel therapy for multiple myeloma. However, direct binding of DARA to endogenous CD38 on reagent… Expand
Blood transfusion requirements and independent predictors of increased transfusion requirements among adult patients on extracorporeal membrane oxygenation -- a single centre experience.
BACKGROUND/OBJECTIVES More adults undergo extracorporeal membrane oxygenation (ECMO) now. They have high transfusion requirements. This study described transfusion requirements of adults during ECMO… Expand
An infant with pseudohyperkalemia, hemolysis, and seizures: cation-leaky GLUT1-deficiency syndrome due to a SLC2A1 mutation.
- Waleed M. Bawazir, E. Gevers, +7 authors G. Stewart
- The Journal of clinical endocrinology and…
- 6 April 2012
CONTEXT GLUT1 (glucose transporter 1) deficiency syndrome is a well-known presentation in pediatric practice. Very rare mutations not only disable carbohydrate transport but also cause the red cell… Expand
Prevalence of preoperative anemia, abnormal mean corpuscular volume and red cell distribution width among surgical patients in Singapore, and their influence on one year mortality
- Y. E. Sim, H. E. Wee, Ai Leen Ang, Niresh Ranjakunalan, B. Ong, H. R. Abdullah
- PloS one
- 4 August 2017
Introduction Preoperative anemia and high red cell distribution width (RDW) are associated with higher perioperative mortality. Conditions with high RDW levels can be categorized by mean corpuscular… Expand