Ahmet U. Coskun

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Role of endothelial shear stress in the natural history of coronary atherosclerosis and vascular remodeling: molecular, cellular, and vascular behavior.

Yiannis S. Chatzizisis, Ahmet U. Coskun, Michael Jonas, Elazer R. Edelman, Charles L. Feldman, Peter H. Stone
Journal of the American College of Cardiology
2007

Although the entire coronary tree is exposed to the atherogenic effect of the systemic risk factors, atherosclerotic lesions form at specific arterial regions, where low and oscillatory endothelial… (More)

Prediction of progression of coronary artery disease and clinical outcomes using vascular profiling of endothelial shear stress and arterial plaque characteristics: the PREDICTION Study.

Peter H. Stone, Shigeru Saito, +20 authors Charles L. Feldman
Circulation
2012

BACKGROUND Atherosclerotic plaques progress in a highly individual manner. The purposes of the Prediction of Progression of Coronary Artery Disease and Clinical Outcome Using Vascular Profiling of… (More)

Prediction of the localization of high-risk coronary atherosclerotic plaques on the basis of low endothelial shear stress: an intravascular ultrasound and histopathology natural history study.

Yiannis S. Chatzizisis, Michael Jonas, +9 authors Peter H. Stone
Circulation
2008

BACKGROUND Low endothelial shear stress (ESS) promotes the development of atherosclerosis; however, its role in the progression of atherosclerotic plaques and evolution to inflamed high-risk plaques… (More)

Effect of endothelial shear stress on the progression of coronary artery disease, vascular remodeling, and in-stent restenosis in humans: in vivo 6-month follow-up study.

Peter H. Stone, Ahmet U. Coskun, +9 authors Charles L. Feldman
Circulation
2003

BACKGROUND Native atherosclerosis and in-stent restenosis are focal and evolve independently. The endothelium controls local arterial responses by transduction of shear stress. Characterization of… (More)

Regions of low endothelial shear stress are the sites where coronary plaque progresses and vascular remodelling occurs in humans: an in vivo serial study.

Peter H. Stone, Ahmet U. Coskun, +7 authors Charles L. Feldman
European heart journal
2007

AIM We performed serial intracoronary studies of patients with stable coronary artery disease (CAD) to investigate the relationships among baseline endothelial shear stress (ESS), CAD progression,… (More)

Natural history of experimental coronary atherosclerosis and vascular remodeling in relation to endothelial shear stress: a serial, in vivo intravascular ultrasound study.

Konstantinos C. Koskinas, Charles L. Feldman, +7 authors Peter H. Stone
Circulation
2010

BACKGROUND The natural history of heterogeneous atherosclerotic plaques and the role of local hemodynamic factors throughout their development are unknown. We performed a serial study to assess the… (More)

Thin-capped atheromata with reduced collagen content in pigs develop in coronary arterial regions exposed to persistently low endothelial shear stress.

Konstantinos C. Koskinas, Galina K Sukhova, +12 authors Peter H. Stone
Arteriosclerosis, thrombosis, and vascular…
2013

OBJECTIVE The mechanisms promoting the focal formation of rupture-prone coronary plaques in vivo remain incompletely understood. This study tested the hypothesis that coronary regions exposed to low… (More)

Shear-activated nanotherapeutics for drug targeting to obstructed blood vessels.

Netanel Korin, Mathumai Kanapathipillai, +11 authors Donald E. Ingber
Science
2012

Obstruction of critical blood vessels due to thrombosis or embolism is a leading cause of death worldwide. Here, we describe a biomimetic strategy that uses high shear stress caused by vascular… (More)

Augmented expression and activity of extracellular matrix-degrading enzymes in regions of low endothelial shear stress colocalize with coronary atheromata with thin fibrous caps in pigs.

Yiannis S. Chatzizisis, Aaron B. Baker, +12 authors Peter H. Stone
Circulation
2011

Background- The molecular mechanisms that determine the localized formation of thin-capped atheromata in the coronary arteries remain unknown. This study tested the hypothesis that low endothelial… (More)

Relation of distribution of coronary blood flow volume to coronary artery dominance.

Shingo X. Sakamoto, Saeko Takahashi, +5 authors Charles L. Feldman
The American journal of cardiology
2013

Coronary artery dominance influences the amount and anatomic location of myocardium that is perfused by the left or right coronary circulation. However, it is unknown whether coronary artery… (More)

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