Ahmet S. Ozcan

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Hyperinsulinism of infancy is a major cause of persistent hypoglycaemia in the newborn period. Transient mild self-limiting hyperinsulinaemia and hypoglycaemia have been described in neonates born to mothers taking ritodrine therapy for premature labour. Ritodrine crosses the placental barrier and enters the fetal circulation readily but the mechanism of(More)
In protein tyrosine phosphatase 1B (PTP1B), the flexible WPD loop adopts a closed conformation (WPDclosed ) in the active state of PTP1B, bringing the catalytic Asp181 close to the active site pocket, while WPD loop is in an open conformation (WPDopen ) in the inactive state. Previous studies showed that Asp181 may be protonated at physiological pH, and(More)
Formation of new synapses between neurons is an essential mechanism for learning and encoding memories. The vast majority of excitatory synapses occur on dendritic spines, therefore, the growth dynamics of spines is strongly related to the plasticity timescales. Especially in the early stages of the developing brain, there is an abundant number of long,(More)
Respiratory syncytial virus bronchiolitis is the most common lower respiratory tract infection in infancy. There is no effective therapy for RSV bronchiolitis. To investigate the efficacy of clarithromycin in the treatment of RSV bronchiolitis, we conducted a randomized, double-blind, placebo controlled trial comparing clarithromycin with placebo in 21(More)
Protein tyrosine phosphatase 1B (PTP1B) is a negative regulator of insulin and leptin signaling, and is therefore a major molecular target for the treatment of type II diabetes and obesity. WPD loop is a key element in the mechanism of PTP1B catalysis. In the apo form, WPD loop is usually in an “open” conformation, whereas it closes over the(More)
Spiders exist in every place and ecosystem. Spiders in tropical regions are particularly poisonous and can be dangerous to humans. Nearly 20,000 spider species are known, and almost all are venomous, although only 60 species worldwide are poisonous in humans. In our area, eight species are reported as poisonous in humans. Although most cases of spider bite(More)
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