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Transient Regenerative Potential of the Neonatal Mouse Heart
The heart in a newborn mouse can rebuild itself after injury, but this regenerative capacity is lost within a few days. Certain fish and amphibians retain a robust capacity for cardiac regenerationExpand
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The distinct metabolic profile of hematopoietic stem cells reflects their location in a hypoxic niche.
Bone marrow transplantation is the primary therapy for numerous hematopoietic disorders. The efficiency of bone marrow transplantation depends on the function of long-term hematopoietic stem cellsExpand
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Hippo pathway effector Yap promotes cardiac regeneration
  • M. Xin, Y. Kim, +11 authors E. Olson
  • Medicine, Biology
  • Proceedings of the National Academy of Sciences
  • 5 August 2013
The adult mammalian heart has limited potential for regeneration. Thus, after injury, cardiomyocytes are permanently lost, and contractility is diminished. In contrast, the neonatal heart canExpand
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Regulation of neonatal and adult mammalian heart regeneration by the miR-15 family
We recently identified a brief time period during postnatal development when the mammalian heart retains significant regenerative potential after amputation of the ventricular apex. However, oneExpand
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Macrophages are required for neonatal heart regeneration.
Myocardial infarction (MI) leads to cardiomyocyte death, which triggers an immune response that clears debris and restores tissue integrity. In the adult heart, the immune system facilitates scarExpand
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The Oxygen-Rich Postnatal Environment Induces Cardiomyocyte Cell-Cycle Arrest through DNA Damage Response
Bao N. Puente,1,3,12 Wataru Kimura,1,12 Shalini A. Muralidhar,1 Jesung Moon,3 James F. Amatruda,1,2,3 Kate L. Phelps,4 David Grinsfelder,5 Beverly A. Rothermel,1,2 Rui Chen,1 Joseph A. Garcia,1 CelioExpand
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Meis1 regulates postnatal cardiomyocyte cell cycle arrest
The neonatal mammalian heart is capable of substantial regeneration following injury through cardiomyocyte proliferation. However, this regenerative capacity is lost by postnatal day 7 and theExpand
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MicroRNA-214 protects the mouse heart from ischemic injury by controlling Ca²⁺ overload and cell death.
Early reperfusion of ischemic cardiac tissue remains the most effective intervention for improving clinical outcome following myocardial infarction. However, abnormal increases in intracellular Ca²⁺Expand
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Nerves Regulate Cardiomyocyte Proliferation and Heart Regeneration.
Some organisms, such as adult zebrafish and newborn mice, have the capacity to regenerate heart tissue following injury. Unraveling the mechanisms of heart regeneration is fundamental toExpand
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Surgical models for cardiac regeneration in neonatal mice
Although amphibian and fish models of heart regeneration have existed for decades, a mammalian equivalent has long remained elusive. Our discovery of a brief postnatal window for heart regenerationExpand
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