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The potency of methylenedioxymethamphetamine (MDMA) as a mechanism-based inhibitor of CYP2D6 has been defined using microsomes prepared from yeast expressing the enzyme and from three human livers. The inhibitory effect was increased by preincubation through formation of a metabolic intermediate complex. Inactivation parameters (kinact and KI), defined with(More)
The nuclear transcription factor, CCAAT/enhancer binding protein alpha (C/EBPalpha) is expressed at high levels in the liver and inhibits growth in cultured cells. We have tested the correlation between C/EBPalpha levels, cell cycle proteins and hepatocyte proliferation in old and young animals as an in vivo model system in which the proliferative response(More)
Advisor Date ii DEDICATION I would like to dedicate my work to my husband Mohammad Saklayen who stood by me at every stage and supported me throughout my studies. Without his help I wouldn't be where I am now. I would also like to dedicate it to my loving parents Md. Alauddin and Maksuda Khanam who always encouraged me to pursue higher studies. I would also(More)
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