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Hair bundles of the inner ear have a specialized structure and protein composition that underlies their sensitivity to mechanical stimulation. Using mass spectrometry, we identified and quantified >1,100 proteins, present from a few to 400,000 copies per stereocilium, from purified chick bundles; 336 of these were significantly enriched in bundles. Bundle(More)
The first release of hardware transactional memory (HTM) as commodity processor posed the question of how to efficiently handle its best-effort nature. In this paper we present Part-HTM, the first hybrid transactional memory protocol that solves the problem of transactions aborted due to the resource limitations (space/time) of current best-effort HTM. The(More)
The precise morphology of the mechanosensitive hair bundle requires seamless integration of actin and microtubule networks. Here, we identify Acf7a (actin crosslinking family protein 7a) as a protein positioned to bridge these distinct cytoskeletal networks in hair cells. By imaging Acf7a-Citrine fusion protein in zebrafish and immunolabeling of vestibular(More)
—Software Transactional Memory (STM) systems are increasingly emerging as a promising alternative to traditional locking algorithms for implementing generic concurrent applications. To achieve generality, STM systems incur overheads to the normal sequential execution path, including those due to spin locking, validation (or invalidation), and commit/abort(More)
Transactional data structures with the same performance of highly concurrent data structures enable performance-competitive trans-actional applications. Although Software Transactional Memory (STM) is a promising technology for designing and implementing transactional applications, STM-based transactional data structures still perform inferior to their(More)
PURPOSE To verify the association between lower urinary tract symptoms (LUTS) and erectile dysfunction (ED) and evaluate the influence of sildenafil and doxazosin either as single agents or combined on both symptoms. MATERIAL AND METHODS A prospective randomized study including 150 patients presented with LUTS caused by BPH in association with clinically(More)