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Synthesis of aryl cyclopropyl sulfides through copper-promoted S-cyclopropylation of thiophenols using cyclopropylboronic acid
TLDR
The copper-promoted S-cyclopropylation of thiophenols using cyclopropylboronic acid is reported, and the reaction tolerates substitution in ortho-, meta- and para-substitution as well as electron-donating and electron-withdrawing groups. Expand
Development of LM98, a Small-Molecule TEAD Inhibitor Derived from Flufenamic Acid.
TLDR
LM98 shows strong affinity to TEAD, inhibits its autopalmitoylation and reduces the YAP-TEAD transcriptional activity, demonstrating the value of this transcription factor for the development of novel anti-cancer therapies. Expand