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The Ros-type regulator MucR is one of the few transcriptional regulators that have been linked to virulence in Brucella. Here, we show that a Brucella abortus in-frame mucR deletion strain exhibits a… Continue Reading
Iron transport has been linked to the virulence of Brucella strains in both natural and experimental hosts. The genes designated BAB2_0837-0840 in the Brucella abortus 2308 genome sequence are… Continue Reading
Brucella strains are Gram-negative bacteria that cause abortion and infertility in their natural animal hosts resulting in extensive economic losses. Humans can acquire a chronic, debilitating… Continue Reading
The combined incidence of melanoma and non-melanoma skin cancer (NMSC) is greater than the incidence of all other malignancies in the US. Previously, we demonstrated that the endocannabinoid,… Continue Reading
Colorectal cancer (CRC) is the third leading cause of cancer-related deaths in the United States. Common chemotherapeutic regimens for CRC include a combination of chemotherapeutic agents to produce… Continue Reading
Fe is an essential micronutrient for Brucella strains. Meeting their physiologic need for this metal is especially challenging for these bacteria because they live in close association with their… Continue Reading