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Sensitization of the Hypothalamic-Pituitary-Adrenal Axis in a Male Rat Chronic Stress Model.
Stress activation of the hypothalamic-pituitary-adrenal (HPA) axis is regulated by rapid glucocorticoid negative feedback. Chronic unpredictable stress animal models recapitulate certain aspects ofExpand
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Engineering a Prokaryotic Cys-loop Receptor with a Third Functional Domain*
Background: Eukaryotic Cys-loop receptors contain three domains, whereas prokaryotic ones contain two because they lack the intracellular domain (ICD). Results: Functional chimeras were engineered byExpand
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Gastroparesis as the Sole Presenting Feature of Neuromyelitis Optica
A 33-year-old African-American woman recently diagnosed with severe idiopathic gastroparesis was readmitted for hypoxic respiratory failure secondary to aspiration pneumonia. A fiber-optic endoscopicExpand
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Skin Necrosis After Ado-Trastuzumab Emtansine Extravasation.
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Artist’s Statement: Unabridged
Eukaryotic-Prokaryotic Chimeras for Structure-Function Studies of the Intracellular Domain of Cys-Loop Receptors
Receptors belonging to the Cys-loop gene superfamily of neurotransmitter-gated ion channels (e.g. acetylcholine, serotonin, GABA, and glycine receptors) mediate fast synaptic transmission. TheseExpand