Ahmed Abdalla Ali

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Crinum is an important Amaryllidaceous plant thanks to the valuable biological and therapeutic activities of its chemical constituents, especially alkaloids. Many Crinum species have been commonly used in traditional medicines worldwide. Long ago, they have been subjected to extensive chemical, cytological and pharmacological investigations. Accordingly,(More)
Mutants of influenza virus that encode C-terminally truncated NS1 proteins (NS1-truncated mutants) characteristically induce high interferon responses. The dual activity of interferon in blocking virus replication and enhancing the development of adaptive immune responses makes these mutants promising as self-adjuvanting live-attenuated influenza vaccine(More)
Highly pathogenic avian influenza virus (HPAIV) H5N1 has been endemic in Egypt since 2006, and there is increasing concern for its potential to become highly transmissible among humans. Infection by HPAIV H5N1 has been described in experimentally challenged birds. However, the pathogenicity of the H5N1 isolated in Egypt has never been reported in naturally(More)
The current inactivated influenza vaccines provide satisfactory protection against homologous viruses but limited cross-protection against antigenically divergent strains. Consequently, there is a need to develop more broadly protective vaccines. The highly conserved extracellular domain of the matrix protein 2 (M2e) has shown promising results as one of(More)
The continuous exposure of cats to diverse influenza viruses raises the concern of a potential role of cats in the epidemiology of these viruses. Our previous seroprevalence study of domestic cat sera collected during the 2009 H1N1 pandemic wave (September 2009-September 2010) revealed a high prevalence of pandemic H1N1, as well as seasonal H1N1 and H3N2(More)
Crinum is a well-known traditional herb belongs to family Amaryllidaceae. Worldwide, different Crinum species are commonly used to treat various conditions due to their excellent medicinal values. Members of this genus are also best known biofactories for the unique Amaryllidaceae alkaloids. Due to the significant phytoconstituents produced by this plant as(More)
Crinum is an important and fascinating genus of the large and equally captivating Amaryllidaceae family. Owing to the valuable biological effects and therapeutic potentials of its chemical constituents, many Crinum species have a worldwide folkloric reputation. Additionally, Crinum species have been subjected to extensive chemical, cytological and(More)
Crinums occupy an important position within plants of family Amaryllidaceae, and many of them have been broadly used in traditional and ethnomedicines throughout the world. Due to their richness in bioactive phytoconstituents, Crinums have been subjected to extensive chemical, cytological and pharmacological investigations that focused chiefly on their(More)