Ahmad Mohamed Sira

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BACKGROUND & AIMS The dilemma of early diagnosis of biliary Atresia (BA), particularly distinguishing it from other causes of neonatal cholestasis is challenging. The aim was to design and validate a scoring system for early discrimination of BA from other causes of neonatal cholestasis. METHODS A twelve-point scoring system was proposed according to(More)
AIM Early diagnosis of biliary atresia (BA) is of utmost importance for good outcome; however, it is sometimes difficult due to the overlapping diagnostic test results with other causes of neonatal cholestasis. Moreover, many diagnostic tests are costly, invasive and not available in all centers, especially in developing countries. So, we aimed to(More)
A technical description of a pulsed, multifrequency photoplethysmograph is given. It has four channels, thus featuring two probes, each with two different wavelengths. In this study 950 and 560 nm are used. The penetration depth of light in skin is wavelength dependent, thus making it theoretically possible to record vascular changes in different layers of(More)
OBJECTIVES Discrimination of biliary atresia (BA) from other causes of neonatal cholestasis (NC) is challenging. We aimed to analyze the clinicopathological findings in cholestatic infants who were provisionally diagnosed with BA and then excluded by intraoperative cholangiography compared with those with a definitive diagnosis of BA and to shed light on(More)
OBJECTIVES The etiology of biliary atresia (BA) is still elusive. Inflammation plays a key role in bile duct and liver injury. The recruitment and accumulation of inflammatory cells is largely dependent on adhesion molecules. We aimed to investigate P-selectin (CD62P) expression in liver tissue in patients with BA compared with other neonatal cholestatic(More)
5 Discussion MORRIS (1973) has described how many bioengineers have at some time attempted to use an accelerometer to study human movement. These attempts have usually failed because of the unsuitability of the accelerometer, either because of its poor low-frequency response or because of its excessive bulk and prohibitive price. The current work has used(More)
We read with great interest the article by B eland et al. in a recent issue of HEPATOLOGY. They investigated the possible role of B cells in the pathogenesis of autoimmune hepatitis (AIH) and the beneficial effect of B-cell depletion on disease remission. They demonstrated that anti-CD20 resulted in a drastic reduction of liver inflammation accompanied by a(More)
To the Editor: We read with great interest the paper by El-Guindi et al. [1], evaluating a new diagnostic score for biliary atresia (BA). BA is a destructive inflammatory obliterative cholangiopathy of unknown origin that affects intraand extrahepatic bile ducts. Success of surgical correction, in form of a Kasai portoenterostomy amongst other factors,(More)
High serum cholesterol and LDL-cholesterol level and high blood pressure are risk factors for cardiovascular disease (CVD). CVD risk factors usually occur simultaneously, fact that enhance personal and population CVD risk. Data from interventional studies suggest that reducing CAD risk factors significantly lowered risk of CAD. Fluvastatin, a statine, has(More)
1 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 102 103 104 105 106 107 108 109 110 Dear Editor: We read with great interest the article by Klemann et al in a recent issue of Gastroenterology. They investigated the role of interleukin 17A produced by gd T cells in the pathogenesis of biliary atresia (BA) in a(More)